Qaar ka mid ah cilmi-baarayaasha ayaa aaminsan in astaamaha amfi-yada 'hypothesis hypothesis' ay si fiican u sharraxaan sababta cudurka Alzheimers .
In kasta oo su'aalo badan oo aan weli laga jawaabin, waxa la yiraahdo 'hypothesis' oo la yiraahdo "peptide" oo la yiraahdo amyloid-beta waa dhacdo muhiim ah ee cudurka Alzheimers: Dhibaatadani waxay ka dhacdaa dhacdooyin taxane ah oo keena dhimashada unugyada maskaxda, Cudurka Alzheimer.
Sidee Amyloid-Beta ugu dhici kartaa Alzheimers
Amyloid-beta waxaa laga sameeyaa borotiin fara badan oo la yiraahdo borotiinka amyloid precursor (APP). Cilmi baadhayaashu ma ogaan karaan hawsha APP weli, laakiin waxay saameyn kartaa waxqabadka unugyada maskaxda. Enzymes-ga gaarka ah (oo loo yaqaanno qarsoodi) ayaa ku dhuftay borotiinkan meelo gaar ah, mid ka mid ah waxyaabaha ka mid ah "xoqitaanka" waa peptide amyloid-beta peptide. Cudurradaas amyloid-beta peptide waxay isku xiri karaan waxa loo yaqaan 'oligomers', iyo sida loo yaqaan 'hypothesis', waxay noqonaysaa oligomers kuwaas oo ah sunta unugyada maskaxda, taas oo keeni karta dhibaatooyinka hore ee garaadka Alzheimers. Later, oligomers waxay sameeyaan dabaqyo udubdhexaad ah cudurka Alzheimers, laakiin waa oligomers - oo ka soo horjeeda dabaqyada - kuwaas oo ah walxaha dhabta ah ee sunta ah.
Inkastoo dhowr jeer oo cadeymo ah oo taageeraya sharraxa casilaada amyloid, waxaa sidoo kale jira dhowr caqabado ah.
Hal shey, amyloid-beta oo ku urursan dabaqyada ayaa ku dhaca da'da caadiga ah iyo sidoo kale cudurka Alzheimers. Dhinaca kale, keydka borotiinka kale ee la yiraahdo waa noocyo tangles oo isku xira dhibaatooyinka garashada ee Alzheimers 'xanuun badan marka loo eego calaamadaha. Ugu dambeyntii, waxaa jira aragti kale oo badheedh ah, sida maskax-mareenka maskaxda, kaas oo lagu soo jeediyay sharraxaad ka bixinaysa waxa keena cudurka Alzheimers.
Xigasho:
Christensen DD. Cudurka Alzheimer: Horumarinta horumarinta cudurka anti-amyloid- wax ka beddelidda daaweynta. CNS Spectr. 2007; 12: 113-123.
- Qodobka ay qoreen Esther Heerema, MSW