Beta Amyloid Protein, Plaque, iyo Alzheimers

Protein Beta-amyloid iyo plaque - kuwani waa laba shuruudood oo ku xiran maskaxda isbedelka cudurka Alzheimers. Ma rabtaa inaad wax dheeraad ah ogaato? Halkan waxaa ku qoran 9 xaqiiqooyin:

1. Kobcinta borotiinka beta-amyloid ee maskaxda ayaa loo tixgeliyaa inay tahay mid ka mid ah calaamadaha Alzheimers . (Qodobka kale ee muhiimka ah waa tangles neurofibrillary .) Feeraha beta-amyloid waxay isku wada duubaan si ay u sameeyaan xalka (aan awoodin in la kala diro) dabaqyada ka baxsan qanjidhada.

1. Cudurka Beta-amyloid sidoo kale wuxuu isku dhejiyaa isku-imaadyada iyo faragelinta isgaadhsiinta unugyada kale ilaa maskaxda.
2. Ka hor intaanay jirin koox beta-amyloid ah oo weyn oo loogu yeero lakab , borotiinnadaas waxay marka hore sameeyaan oligomers . Oligomers weli waa la xalin karaa (awood u leh in la kala diro), kooxaha yar yar ee beta-amyloid.
3. Inkasta oo calaamadihii hore loo aqoonsaday inay yihiin mid ka mid ah sababaha Alzheimers, cilmi-baarayaashu waxay dhawaan ku magacawday arimahan, aqoonsashada oligomers-kii kor ku xusan ee laga yaabo inay noqoto mid ka mid ah dambiilayaasha ugu waaweyn ee ka hortagga isgaadhsiinta unugyada. Hal sabab oo ka dambeeya tani waxay tahay in dadka qaarkiis ay huuri karaan maskaxda, hase yeeshee ma laha astaamaha cudurka Alzheimers .
4. Waxaa intaa sii dheer, cilmi-baarisyo kale ayaa muujiyey in isbeddelka fahamka uu muuqanayo inuu bilaabmayo ka hor inta aan la helin borotiinka beta-amyloid oo ka soo jeeda farqiga weyn ee huurada.
5. Saynisku wuxuu helay borotiinada beta-amyloid in ka badan 100 sano ka hor. Waxay markii ugu horreysay u aqoonsadeen Dr. Alois Alzheimer sannadkii 1906.

1. Beta-amyloid waa qayb ka mid ah borotiinka ka weyn oo la yiraahdo borotiinka amyloid precursor .
2. Cilmi-tusaale: "Cilmi-yaqaanno badan ayaa sidoo kale u maleynaya in dabaqyada dhabta ah ay noqon karaan iskuday dabiiciga ah ee maskaxda si loo helo beta-amyloid waxyeello ka soo jeedda qanjirada" (Alzheimer's Education and Referral Centre).
3. Cilmi-baaris lagu sameeyey Xarunta Cudurrada UC Davis Alzheimer ayaa ogaaday in habka difaaca jirka uu uga jawaab-celiyo sidii lafo-xumada u yeelatay bakteeriyada, taasoo keentay bararka maskaxda oo waxyeeleeyay neur-mareenka. Caabuqa maskaxda ayaa ku xiran cudurka Alzheimers.

Ilaha:

_{Ururka Alzheimers. Alzheimers 'Drugs Targeting Beta-Amyloid iyo "Amyloid Hypothesis." 2008.}

_{Ururka Alzheimers. Faahfaahin dheeraad ah oo ku saabsan Plaques.}

_{Ururka DANA. Amyloid-Beta 'Oligomers' waxay ku xiran tahay Dementia Alzheimers. Julaay 12, 2010.}

_{Machadka Qaranka ee Gabowga. Xarunta Waxbarashada Cudurka Alzheimer iyo Xarunta gudbinta. Janaayo 22, 2015.}

_{Stanford Medicine. Cilmi-baadhayaashu waxay muujinayaan sida Beta-amyloid ay u dhici karto Alzheimers. Sebtembar 2013.}

_{Nidaamka Caafimaadka ee UC Davis. Alzheimer's sabab u ah Amyloid iyo Bakteeriya Trigger jawaab celinta Immune.}