Kansarka Ovarianis ee Epiteliyal ah, Jermiska Cell, iyo Calaamadaha Cudurka Dabeecadda Dhallaanka
Sida bukaanka kansarka ugxan-sidaha ah, waxaad u maleyneysaa in aad ku socotid ereyga "calaamadaha kansarka." Laakiin maxay micnaheedu tahay?
Kansarka qanjirrada (ovarian cancer) waxaa loogu magac daray sababtoo ah waxay ka timaadaa ugxan (ama tuubooyinka dhuunta ee ku xiga ugxan.) Laakiin waxaa jira noocyo badan oo unugyada kala duwan ah ee ugxansiisyada , iyo nooc kasta oo unugyadaas ah ayaa noqon kara kansar. Noocyadaas oo dhan waxay leeyihiin shaqooyin kala duwan waxayna soo saaraan walxo kala duwan oo ah biochemical.
Walxahaas waxaa lagu cabbirikaraa dhiiga waxaana lagu magacaabaa calaamadaha tumor.
Waa maxay sababta Dhakhtarkaagu u ordi doono Tijaabada Aaladaha Daroogada Dhiiga
Xaaladaha qaarkood, calaamadaha calaamadaha caanuhu waa maaddo la soo saaro unugyo aan caadi ahayn. Si kastaba ha noqotee, xaaladaha badankood, calaamadahaas ayaa si fudud loo soo saaraa heerar aan caadi aheyn iyada oo unugyada kansarku ay soo rogeen qaybo kala duwan oo ka mid ah mashiinnada biochemical. Dhakhaatiirtu waxay tixraacaan burooyinka oo soo saara xaddi badan oo ka mid ah walxahan sida burooyinkaas sheegaan calaamadahaas. Tusaale ahaan, halkii laga dhihi lahaa kansarka ugxan-sidaha ee soo saara qadar badan oo ah CA-125, waxay sheegi karaan in kansarku muujinayo CA-125 .
Noocyada Kansarka Ovarianka
Xaalad kasta, tani macnaheedu waa in dhakhtarkaagu uu hubin karo dhiiggaaga si uu u baaro calaamadaha burooyinka, oo muujinaya nooca kansarka jira, ama ka dib, sida fiican ee daaweyntaadu u shaqeyso. Guud ahaan, calaamadaha bukaanka ayaa hoos u dhaca marka daaweyntu ay wax ku ool noqoto.
Kansarka ugu badan ee ugxansidaha waxaa lagu magacaabaa kansarka xubinta taranka ee epithelial. Waxa jira saddex nooc: maskaxda, xajmiga iyo endometrioid. Noocyada naadirka ah ee kansarka ugxan-la'aanta ah waxaa lagu magacaabaa kansarka unugyada germ ee galmada iyo jinsiga. Mid kasta oo ka mid ah ayaa leh dhowr nooc, laakiin calaamadaha ayaa isku mid ah mid kasta oo ka mid ah kooxahan waaweyn.
Calaamadaha Kansarka Kansarka ah ee Kansarka
Baaritaanka dhiigga ee calaamadaha calaamadaha CA-125 ayaa ah calaamada ugu caansan ee loo isticmaalo kooxahan kansarrada. CA waxay u taagan tahay "antigen kansarka." CA-125 waxaa lagu sameyn karaa unugyada caadiga ah laakiin waxaa lagu sameeyaa qaddar badan oo ka mid ah unugyada kansarka ugxanta oo ah unugyada caadiga ah ee unugyada.
CA-125 waxaa loo isticmaali karaa qayb ka mid ah khatarta halista ah ee ugxan-sidaha ah si loo baadho kansarka ugxan-sidaha, ama waxaa loo isticmaali karaa in lala socdo jawaabta daaweynta kansarka ugxan-sidaha. Kansarrada guud ee kansarka oo dhan ayaa cadeynaya CA-125, heerarkuna waa caadi ahaan qiyaastii 20% noocyada kansarka ugxan-sidaha ah. Taas bedelkeeda, burooyinka cagaarshoowga ah, iyo sidoo kale shuruudo kale, ayaa laga yaabaa inay keenaan heerka sare ee CA-125.
Saddexda nooc ee kansarka epideliyanka ah, kansarrada muuska ayaa aan loo dhigin inay muujiyaan CA-125 marka la barbar dhigo burooyinka cagaaran ama endometrioid.
HE4 - borotiinka epididymis 4 waa calaamadaha cusub ee caanaha oo laga yaabo in lagu muujiyo kansarka ugxan-sidaha, iyo sida CA-125 waxay u badan tahay in la helo cirridka xajiinta iyo endometrioid. Cilmi-baareyaasha qaarkood waxay ogaadeen in isticmaalka isku-jirka ee CA-125 iyo HE4 ay ka caawiyaan baarista kansarka ugxanta haweenka marka loo eego mid kasta oo tijaabo loo isticmaalo oo keliya.
Maadaama dumarka da'doodu ka yar tahay 40 jir ay u badan tahay in ay qabaan noocyada kansarka epithelial ee kansarka ugxan-sidaha, kuwan 2 calaamadood oo buraash ah ayaa laga yaabaa in ay ka caawiyaan geeddi-socodka lagu ogaanayo haweenka da'da yar.
Calaamadaha kale ee burooyinka ee mararka qaar waxay faa'iido u yeelan karaan kormeerida kansarka ugxan-badan ee kansarka ah waa CA-72-4, CA-19-9 iyo CEA (carcinoembryonic antigen). Waxaa jira kuwo kale oo laga yaabo inay sare u qaadaan laakiin inta badan aan la isticmaalin. CA 19-9 badanaa waxaa laga helaa dumarka leh noocyada muusikada oo laga yaabo in ay ku caawiyaan habka ogaanshaha marka lagu daro CA-125.
Calaamadaha Cudurka Jermiska-Unugyada
Labada calaamadood ee ugu muhiimsan ee loogu talagalay kooxahan kansarrada ah waxay ka kooban yihiin: alaabooyinka protein (AFP) iyo gonadotropin bini-aadanka ah (hCG) . Dhamaadka waxaa sidoo kale loo isticmaalaa in lagu ilaaliyo uurka. Heerarka AFP iyo HCG oo aad u sarreeya ayaa ah hab aad u sarreeya oo lagu ogaado kansarkaan.
Calaamadaha Calaamadaha Isku-dhafan ee Cudurka
Calaamadaha kaliya ee qeybtan oo faa'iido leh waxaa soo saarey qaybta hoose ee granulosa. Kuwaas waxaa ka mid ah estradiol (nooc ka mid ah estrogen) iyo inhibin . Maaddaama burooyinkaas badanaa laga helo dumarka da'da yar , baaritaanadaas waxaa laga yaabaa in la sameeyo iyada oo qayb ka ah shaqeyn loogu talagalay tiro caloosha ah (iyo astaamaha kale sida qaangaadhka qatarta ah) gabdhaha iyo haweenka da'da yar.
Ilaha:
Berek, Johanthan S. "Cilmi-baaris Dhaqtarka Haweenka ah." Lippincott Williams & Wilkins, 2004
Carlson, K. Baaritaanka Kansarka Ovarian. UpToDate. La daabacay 03/01/16.
Hu, M., Guan, H., Lau, C. et al. Warbixin ku saabsan qiimeynta qalliinka daaweynta ee β-hCG iyo αFP ee kaansarta unugyada jeermiska ee unugyada. Joornaalka Yurub ee Cilmi-baarista Caafimaadka . 2016. 21 (1): 10.
Santororibio, J. Waa maxay calaamadaha calaamadaha ugu caansan ee si fiican u tilmaamaya kansarka ugxanta haweenka? Association of Chemistry Association. 01/20/16.
Soletormos, G., Duffy, M., Hassan, S. et al. Isticmaalka Isticmaalka Klinikada Kansarka Biomarkers ee Kansarka Mucaaradka ee Epiteliyanka ah ayaa soo cusbooneysiiyay Tilmaamaha ka yimid Kooxda Yurubta ah ee Ku-Meel-Gaarka ah. Wargeyska Caalamiga ah ee Kansarka Caafimaadka dumarka . 2016. 26 (1): 43-51.
Uma, D., Purushotham, N., Jayashree. Maareynta Kansarka Ovarian ee Haweenka Da'da yar. Dib u eegista Dacwadaha Dhakhaatiirta ee dhawaan . 2015. 10 (4): 263-9.