Daawada methotrexate waa daawo wax ka beddeleysa daawada antirowmatic (DMARD) loo isticmaalo daaweynta xanuunka rheumatoid iyo cudurada kale ee rheumatiska. Qiyaasta loo isticmaalo rheumatoid arthritis waxaa loo tixgeliyaa mid hooseeya. Dhiigga, methotrexate waxaa kale oo loo isticmaalaa daaweynta qiyaasta sare ee kansarka iyo qiyaasta sare si loo joojiyo uurka.
Farsamo ahaan, methotrexate waa dihydrofolate reductase inhibitor kaasoo saameynaya dheef-shiid kiimikaad.
Taasi waxay tidhi, waxay u horseedi kartaa waxyaabo aan caadi ahayn oo ku jira ribonucleic acid iyo qalabka deoxyribonucleic acid. Methotrexate waa teratogen la yaqaan, taas oo lagu qeexay walax kasta, aaladdiisa, ama habka keena ciladaha uurjiifka ah. Daawada methotrexate waxay sababi kartaa muuqaalada dysmorphic, cilladaha dhakada iyo addimada, yaraanta koritaanka, dib-u-dhiska koritaanka, iyo maskax-dari maskaxeed.
Awoodaha uur-ku-jirta uur-jiifka waxay ka dhigaysaa daroogada welwel ku ah da'da da'da ilmaha, kuwa qorshaynaya inay uuraystaan, iyo gaar ahaan kuwa uur leh marka lagu daaweeyo daawada methotrexate.
Ciladaha uur-ku-jirka iyo Uurka ee la Xiriira Methotrexate
Dumarka waa in la ogaadaa halista uur-ku-jirta iyo uur-ku-jirka oo la xidhiidha daawada methotrexate, xitaa inkastoo heerka uur-ku-jirka uur-ku-jirka uurku hooseeyo. Daraasad Faransiis ah, haweenka qabta xanuunka dabaysha dabiiciga ah ee lagu daaweeyay methotrexate oo hooseeya muddada saddexda bilood ee hore ayaa la qiimeeyay.
28ka xaaladood ee la falanqeeyay, methotrexate ayaa la joojiyay ka hor inta aan la gaarin 8da toddobaad ee uurka 26 haween ah. Afar dumar ah ayaa dhicisoobay, 5kuna waxay joojiyeen joojinta uurka. Waxaa jiray 19 dhalasho nool, kuwaas oo 3 ka mid ah ay dhicin. Cilmi baadhayaashu waxay soo gabagabeeyeen in natiijooyinkoodu ay taageerayaan fikradda ah in aysan jirin halis teratogenic ah oo leh daawada methotrexate oo hooseeya, taasoo bixisa daroogada la joojiyo horay uurka uurka.
Daraasad kale waxay eegtey 8 uur qaadasho methotrexate-uur-ku-jirta. Waxaa jiray hal xaalad oo ah mid loo yaqaan 'embryopathy methotrexate' oo caadi ah. Waa kiiskii kowaad ee noocan oo kale ah oo laga helo dadka qaata qiyaasta hal toddobaadlaha ah ee daawada methotrexate (qiyaasta caadiga ah ee cudurada rheumatiska). Inkasta oo ay ahayd hal kiis oo keliya, cilmi-baarayaashu waxay ku soo gabagaboobeen in mabda'aanka methotrexate ee qiyaasaha hoose uu yahay mid waqti go'an ah.
Maxaa ku saabsan Ragga?
Sida laga soo xigtay Drugs.com, uurka waa in laga fogaadaa labada xaas ama lamaane lagu daaweynayo daawada methotrexate. Uurka waa in laga fogaadaa inta lagu jiro daweynta iyo ugu yaraan 3 bilood ka dib daawaynta bukaanka labka ah, iyo inta lagu jiro daweynta iyo ugu yaraan hal wareeg oo daawada ka dib daaweyn loogu talagalay bukaannada dumarka ah.
Waxaa jira halis halis ah oo ah isbedelka shahwada ee ragga ee qaadanaya daawada methotrexate, laakiin aan la xaqiijin. Sidoo kale, sida laga soo xigtay Jariidada Rheumatology , miyir-qaadista methotrexate ee wakhtiga rimidda uma muuqato in ay soo gudbiso welwel ama arimaha uur-jiifka.
Khadadka hoose
Ma jiro boqol% 100 oo amni ah oo ku saabsan maaddada methotrexate ee uur-ku-jirka. Saameynta daawada methotrexate u muuqato mid aan la saadaalin Karin, qayb ahaan sababo kala duwanaanshaha hidde-qabadka ee jawaabta dhulalka iyo uurjiifka ee sunta.
Ka dib marka la qaadayo daawada methotrexate inta lagu jiro seddexda bilood ee ugu horeeya, hooyada dooraneysa inay sii wadato uurka waa inay ogaadaan in ay jirto 10/42 fursado aan caadi aheyn ee uurjiifka ah (QJM: Wargeyska Caalamiga ah ee Daawada).
Sida laga soo xigtay Kelley 'Textbook of Rheumatology , dumarka waxaa lagula talinayaa in ay joojiyaan daawada methotrexate ugu yaraan 3 bilood ka hor intaysan dhalmada. Daaweynta Folic acid waa in la sii wado ilaa uurka. Kolajka American College of Rheumatology wuxuu kugula talinayaa isticmaalka ka hortagga uur-qaadida adigoo qaadanaya daawada methotrexate iyo 3 bilood ka dib joojinta daawada methotrexate.
Ilaha:
Methotrexate (Rheumatrex, Trexall). Kulliyadda Maraykanka ee Rheumatology. Michael Cannon, MD May 2012.
http://www.rheumatology.org/Practice/Clinical/Patients/Medications/Methotrexate_(Rheumatrex,_Trexall)/
Methotrexate dose yar ee saddexda bilood ee ugu horreeya ee uurka: natiijooyinka daraasad iskaashi Faransiis ah. Lewden B et al. Wargeyska Rheumatology. December 2004. http://www.ncbi.nlm.nih.gov/pubmed/15570635
Methotrexate Embryopathy Ka Dib Marxaladda Loo Habboonaanta Usbuucii Ugu Horeeya ee Uurka (Early Pregnancy). Martin MC, et al. Takhasuska taranka . Oktoobar 26, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24513926
Digniinta Methotrexate Uurka iyo Naas nuujinta. Drugs.com.
http://www.drugs.com/pregnancy/methotrexate.html
Natiijada Wareerka ee Natiijooyinka Methotrexate iyo Uurka. Wargeyska Rheumatology. Begin, et al. January 15, 2011.
http://www.jrheum.org/content/early/2011/01/11/jrheum.100600
Saameynta daawada methotrexate ee uurka, bacriminta iyo nuujinta. QJM: Wargeyska Caalamiga ah ee Daawada. 1999.
https://academic.oup.com/qjmed/article/92/10/551/1531030/Dhaxfiiqyada-of-methotrexate-on-pregnancy-fertility
Kelley ee buugta qoraalka ee Rheumatology. Elsevier Saunders. Volume I. Uurka uurka ku jira ee Rheumatic. Cutubka 39. Page 552.