Nuujinta hoos loo dhigaa oo la xidhiidha daroogada caanka ah iyo taakulaynta
Isdhexgalka mukhadaraadka daroogada ayaa ah welwel guud oo loogu talagalay dadka qaba HIV iyo dhakhtarkooda daaweynaya, gaar ahaan haddii qofku uu arko khabiiro badan oo takhasus leh oo ku saabsan arrimaha kale ee aan la-qaadin HIV. Inkastoo farmashiyadu ay badanaa ogaan karaan wada-xaajoodyadan marka daawooyinka la qoro, waxaa jira alaabooyin caadi ah oo si sahlan u duuli kara radiyaha farmashiyaha, haddii la qaado, waxay si ba'an u wiiqi karaan saamaynta dawooyinka antiretrovoviral (ARVs).
Waxay sidaas samayn karaan iyaga oo farageliya nuugista ARV-yada qaarkood, xannibaadda enzymes ee loo baahan yahay in lagu dheefshiido daroogada, ama keena koror aan loo baahnayn ama hoos u dhac ku yimaada heerka daaweynta daroogada ARV. Waxaa la yaab leh, qaar ka mid ah alaabooyinkan ayaa ah maalin kasta, alaabta ka soo horjeeda, halka kuwa kale ay yihiin daawooyinka laguu qoro ama kuwa aan daawada laguu qorin inaadan laba jeer ka fikiraynin inaad qaadato duruufaha caadiga ah.
Haddii aad doonayso inaad bilowdo daaweyn antiretroviral ah , had iyo jeer hubi inaad dhakhtarkaaga kala talisid daroogo kasta ama dheeraad ah-oo ay ku jiraan daawooyinka dabiiciga ah ama dabacsan - waxaad qaadan kartaa. Haddii aad horey ugu jirtay daaweynta oo aad qaadato mid ka mid ah alaabtan soo socota ee lagaga hortago habka gaarka ah ee ARV-ga, la hadal dhakhtarkaaga. Waxaad markaa kala hadli kartaa dib-u-eegidaada jadwalka daaweyntaada daroogada, joojinta badeecada ka hortagga, ama bedelida ARV-yada, haddii loo baahdo.
Kiniiniyada Antacids iyo Joojinta
Magnesium- iyo aluminium-ku-jira antacids (sida Maalox, Mylanta, Milk of Magnesia, Tums) waxay nadiifin karaan asiidhaha caloosha si ay u qaataan noocan oo kale si ay si dhab ah u faragaliyaan qaadashada ARV-ga qaarkood.
Antibiotiyada sida kuwaani waxay sharraxaad u geystaan ​​guryahooda dhexdhexaad ah muddo gaaban oo guud ahaan loo maamuli karo laba illaa lix saacadood ka hor ama ka dib qiyaasta.
ARV-yada ay sida ugu badan u saameeyeen daroogooyinkaas waxaa ka mid ah:
- Aptivus (tipranavir) -xanuunku lix saacadood ka hor ama laba saacadood ka dib
- Edurant (rilpivirine) -daad joojiso laba saacadood ka hor ama afar saacadood ka dib
- Rescriptor (delavirdine) -waxaad halis ku jirtaa hal saac ka hor ama laba saacadood ka dib
- Stribild (elvitegravir + cobicistat + tenofovir + emtricitabine) -kareeyo antacid laba saac ka hor ama ka dib
- Tivicay (dolutegravir) -take antacid lix saacadood ka hor ama laba saacadood ka dib
- Triumeq (dolutegravir + ziagen + epivir) -daaku daawo lix saac ka hor ama laba saacadood ka dib
Daawooyinka kale ee loo adeegsado aashito sida aaladaha proton-ka ah (tusaale ahaan, Nexium, Prilosec, Losec, Prevacid) waxay leeyihiin saameyn muddo dheer ah waxayna yareyn kartaa nuugista labada Reyataz (atazanavir) iyo Edurant (rilpivirine) ilaa 78 boqolkiiba iyo 40 boqolkiiba, siday u kala horreeyaan. Sidaa daraadeed, isticmaalka kontoroolka mashiinka proton-ka ayaa ka hortagaya isticmaalka leh ARV-ga gaar ahaaneed iyo daryeelka gaarka ah waa in la qaataa marka la isticmaalayo antagonistayaasha H2-yada sida Tagamet iyo Zantac, sidoo kale.
La xiriir dhakhtarkaaga si aad ugala hadashid isbeddelka daaweynta iyo / ama daawooyinka haddii aad isticmaasho mid ama mid ka mid ah fasalada daroogada ee Reyataz ama Edurant.
St. John Wort
Perforatum Hypericum Perforatum , oo loo yaqaan 'St John's Wort', waa warshad ubax ah oo ay aaminsan yihiin qaar ka mid ah inay leeyihiin anti-bararka, antiviral, antidepressant, iyo guryaha antioxidant. Iyadoo hal falanqeyn oo weyn oo lagu sameeyay 2008-dii ay soo jeedisay in daaweynta dabiiciga ah ay faa'iido u leedahay daaweynta niyad-jabka weyn, hoygeeda kale ee la soo sheegey ayaa weli ku jira calaamad muujinaysa caddayn yar oo lagu taageerayo in badan oo ka mid ah sheegashooyinka.
Marka loo isticmaalo daaweynta antiretroviral therapy, St. John's Wort waxay saameyn kartaa waxqabadka ee enzyme CYP450 3A4, kaas oo u shaqeeya by oxidising molecules daroogada si ay uga saarto jirka. Haddii tani dhacdo, xaddiga daawada xajmiga xajmiga ee HIV-da ee hormoonada HIV (PI) iyo kuwa aan nucleoside dib u celin (NNRTIs) ayaa si weyn hoos loogu dhigi karaa, mararka qaarkoodna boqolkiiba 82. Sidan oo kale, Wort John Wort waa inaan la qaadin ARV-yada soo socda:
- Aptivus (tipranavir)
- Crixivan (indinavir)
- Edurant (rilpivirine)
- Intelis (etravirine)
- Soo gali (saquinavir)
- Kaletra (lopinavir + ritonavir)
- Lexiva (fosamprenavir)
- Norvir (ritonavir)
- Prezista (darunavir)
- Rescriptor (Delavirdine)
- Reyataz (atazanavir)
- Stribild (taas oo saameyn ku leh daawooyinka elvitegravir iyo daawada kiniiniga ee kiniinka isku dhafan)
- Sustiva (efavirenz) ama Atripla (daroogada isku dhafan oo leh efavirenz)
- Viracept (nelfinavir)
- Viramune (nevirapine)
Garlic
Garlic waxaa la aaminsan yahay inay leeyihiin qaar ka mid ah guryaha oo ka hortagi kara ama daaweyn kara tiro cuduro ah, laga bilaabo hargabka iyo cadaadiska dhiigga oo sareeya si loo daweeyo cudurka wadnaha iyo kansarka. Qaar ka mid ah hey'addaha waxay kuxiraan dhismooyinkan kiimikada ku jirta sharoobada loo yaqaan 'allicin'.
Inkastoo daraasaduhu muujiyeen faa'iidooyinka ka iman kara kaalmada dhuxusha - oo ay ku jiraan budada, xayawaanka, koofiyadaha, ama foomka kiniinka - waxaa jiri kara cillado halis ah marka lala wadaago daawada hormoonada hormoon ee protease Invirase (saquinavir). By faragalinta CYP450 3A4 ee xabadka, dheecaannada dhasiga waxay u dhimi kartaa diirada maadada loo yaqaan 'Invirase' ee daroogada 'dose' illaa 54%. Xitaa ka dib marka la joojiyo isticmaalka toonta, daraasaduhu waxay muujiyeen in saameynta cidhiidhiga ay sii socon karto maalmo iyo xitaa toddobaadyo kadib.
Daraasado kale ayaa soo jeediyay in toonta ay sidoo kale saameyn karto bioavailability of PI iyo NNRTIs kale, inkastoo aysan jirin wax khatar ah oo loo isticmaalo isticmaalka mana jiraan talooyin ku saabsan inta ay le'eg yihiin ama qaababka toonta ah (oo ay ku jiraan ceeriin) waxay noqon kartaa mid habboon ama aan habooneyn. Sidan oo kale, haddii aad qaadato nooc kasta oo ah kaalmada caafimaadka, waxaa lagula talinayaa inaad u sheegto dhakhtarkaaga daaweynta.
> Ilo:
> Waaxda Caafimaadka ee Mareykanka iyo Adeegyada Dadweynaha (DHHS). "Tilmaamaha Isticmaalka Aaladaha Antiretroviral ee dadka qaba HIV-1-Infekshan Dadka waaweyn iyo Dhalinyarada." Washington, DC; Janaayo 19, 2015.
> Linde, K .; Berner, M .; iyo Kriston, L. "St John's wort for depression major." Xogta Cochrane ee qiimeynta nidaamka . Oktoobar 8, 2008; (4): CD000448. doi: 10.1002 / 14651858.CD000448.pub3.
> Piscitelli, S .; Burstein, A ;; Welden, N .; et al. "Saamaynta tufaaxa ee daawada farmasokinetiga ee saquinavir." Cudurada Cudurrada Cudurrada ah; 34 (2): 234-238.