Miyuu ku dhacaa nikotiinta kansarka ama keena kansarka inuu faafo? Maxaa saameyn ah nicotin ku leeyahay daaweynta kansarka? Maadaama ay badanaa sigaar cabbista sigaarka ah oo ay ku jirto nicotin ay diyaar yihiin, kuwani waa su'aalo sii kordhaya oo muhiim ah. Dhibaatada halista ah ee faa'idada daaweynta nikotiinka - waxay ka caawin kartaa dadku inay caado u yeeshaan caado-yaqaanno (iyo cuduro badan oo kale.) Dheeraadka kale waa dadka tilmaamaya in nicotinku uu noqon karo dhimasho iyo in horay loo isticmaalay sida cayayaanka.
Saameynta nikotiinta ku jirta Kansarka
Si aad uga jawaabto su'aashan - doorka nicotine ee la xiriira kansarka - su'aasha waa in la jebiyo mowduucyo dhowr ah. Sidaa darteed, waa in aan baarnaa doorka nicotine ee soo socda:
- Tumor bilaabis ama Mutagenicity - Tani waxay loola jeedaa awooda maaddo si ay u keento waxyeellada (isku-baddelidda DNA) lagama maarmaan u ah in loo beddelo unug caadi ah unugyada kansarka .
- Horumarinta Wadnaha / Tumoraha Wadnaha - Tani waxay loola jeedaa awoodda walaxda si ay u keento buro horay u soo baxday si ay u korodho si dhakhso ah iyo / ama faafiso (metastasize) gobollada kale ee jirka ah si deg deg ah.
- Saameyntii Daaweynta Kansarka - Tani waxay tilmaamaysaa saameynta walaxda laga yaabo inay leedahay daaweynta kansarka, tusaale ahaan, haddii walaxda la joojiyo ama ay joojiso dawada kiimiko-daweynta.
Role Nicotine oo Kansarka ah
Inkastoo daraasadaha aan lagu sameynin dhammaan saameynta suurtagalka ah ee nicotin ku saabsan dhammaan kansarrada. Iyo, in badan oo ka mid ah daraasaddaha ilaa taariikhda ayaa lagu sameeyay jiirarka, jiirka, ama unugyada kansarka ee koray shaybaarka, waxaan ognahay waxyaabahan soo socda:
- Saamaynta nikotiinka ee bilowga Tumor ama Mutagenicity - Daraasadihii ugu dambeeyay ayaa muujiyay in nicotin uu leeyahay hawlo mutawiciine ah iyo burooyin dhiirigalin ah. Waxaa sidoo kale jira caddayn ah in nicotin uu keeni karo dhaawac maskaxda ah - nooca waxyeellada keeni karta kansarka. Waxa kale oo jira caddayn ah in nicotine balaadhan geeddi-socodka kansarku-macnaheedu yahay in habka unuggu noqonayo kansar si looga jawaabayo walax kale ayaa la xoojiyaa. Tani macnaheedu maaha inayan khatar u ahayn kuwa aan lahayn kansar. Dhibaatooyinka hoos ku qoran waxay dhici karaan marka kansarku jiro laakiin aan weli la ogaan.
- Saameynta horukaca Tumorka iyo Horumarka - Inkastoo nicotinku mas'uul ka ahayn unugyada ugu horreeya ee kansarka noqda kansar, dhowr daraasado oo dheeraad ah ayaa muujiyay in marka kansar gaar ah uu soo baxo, nicotine wuxuu kor u qaadi karaa koritaanka buro. Tusaale ahaan, nicotine waxaa laga helay inuu dhiirrigeliyo gardarrada kansarka beeryarada ee jiirka. Waxaa sidoo kale lagu ogaaday in ay kor u qaadayso kordhinta, duullaanka, iyo guuritaanka unugyada burooyinka ee kansarka sanbabada unugyada yaryar.
- Saameyntii jawaabaha ee Daaweynta Kansarka - Nicotine ayaa lagu ogaadey in ay faragelinayso qaar ka mid ah daaweynta kansarka, taas oo macnaheedu noqon karo in nicotinku hoos u dhigi karo heerka noolaanshaha kansarka. Tusaale ahaan, nicotinku wuxuu dhiirigelin karaa iska caabinta dawada kemotherabi ee Platinol (cisplatin) ee unugyada kansarka sanbabada.
Waxaa muhiim ah in la ogaado, inta badan cilmi-baaristaan, nicotiinta waxaa si gaar ah loo qiimeeyaa sigaarka cabitaanka sigaarka si loo hubiyo in saameyntu ay sabab u tahay nicotine oo kaliya halkii laga heli lahaa walxo kale oo ku jira tubaakada.
Sidee ayuu Nikotinku u shaqeeyaa kobcinta kobaca iyo faafitaanka iyo yaraynta waxtarka daaweynta
Waxaa jira siyaabo badan oo kala duwan oo nicotin laga helay in ay saameeyaan koritaanka iyo faafidda kansarka.
Kuwaas waxaa ka mid ah:
- Horumarinta bilowga kansarka (sida kor ku xusan).
- Xoojinta kobaca burooyinka (iyadoo kicinaysa borotiinka mas'uulka ka ah qaybinta unugyada iyo koritaanka).
- Fududeynta faafidda kansarka (tusaale, iyada oo la hagaajinayo isbeddelka unugyada kansarka (sida ku xusan hoos).
- Kor u qaadista angiogenesis - Nikotiintu waxay kobcin kartaa kartida kansarrada inay soo saaraan unugyada dhiigga ee cusub ee loo baahan yahay koritaanka iyo ka hortagga dhimashada dabiiciga ah ee unugyada hore ama aan caadi ahayn (apoptosis).
- Iyadoo loo marayo jimicsiga - Iyadoo lagu dhiirigelinayo waddooyinka kala duwan, nicotinku waxay sababi kartaa in bukaanku uu u nugul yahay walxaha kiimiko ah.
Inkastoo sharaxaadda hababka saxda ah ay tahay mid farsamo oo ka baxsan baaxadda qodobkan, dhowr tusaale oo ku saabsan siyaabaha nicotine loo helo inay kor u qaadaan koritaanka iyo faafidda kansarrada waxaa ka mid ah:
- Nikotiintu waxay ku shaqeyn kartaa iyada oo la xakameynayo reseptors lagu magacaabo nicotinic acetylcholine reseptors (nAChRs). Dhab ahaan, tani waa habka nicotinku u yahay mid la qabatimo. Hawlgallada nicotine-ka ee waxqabadka leh waxay kicin karaan korriimada burooyinka, waxay kor u qaadaan sameynta xididdada dhiigga ee cusub ee lagama maarmaanka u ah kansarrada si ay u koraan ( angiogenesis ) ayna joojiyaan dhimashada (apoptosis) unugyada kansarka. Maadaama ay jiraan kala duwanaansho dadka nikotinic acetylcholine ka mid ah shakhsiyaadka kala duwan, saameyntan ayaa sidoo kale laga yaabaa inay ku kala duwan yihiin dadka kala duwan. (Arrin xiiso leh, qaboojin nikoti ah oo xooggan ayaa la xidhiidhaa khatarta sare ee kansarka sanbabada.)
- Nikotiin waxay kicisaa borotiinka loo yaqaan beta-arrestin-1. Kansarkan, waxay sii kordhinaysaa dhaqdhaqaaqa unugyada kansarka qaarkood oo u oggolaanaya inay faafiyaan oo soo qabtaan si fudud.
Kansarka ku xiran Nicotine ee Qaar ka mid ah
Saameynta nicotine-ka ee bilowga, horumarka, iyo jawaabta daaweynta looma baarin dhammaan kansarrada, laakiin waxaa jira caddayn ah in nicotinku uu ka ciyaari karo door waxyeello ugu yaraan hal dariiq oo ah kansarrada soo socda:
- Kansarka sanbabada unugyada yaryar
- Kansarka sanbabada unugyada yar-yar
- Kansarka madaxa iyo qoorta
- Kansarka Gastric (Cancer Cancer)
- Kansarka Pankreatic
- Kansarka Gallbladder
- Kansarka beerka
- Kansarka mindhicirka
- Kansarka naasaha
- Kansarka afka ilmo-galeenka
- Kansarka kaadiheysta
- Kansarka Kelyaha (Kansarka Kansarka Kelyaha)
Ilaha:
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