Ma jiraa xiriir u dhexeeya qoyaanka iyo kansarka sanbabada? Waxaan ognahay inay jiraan farqi badan oo u dhaxeeya kansarka sanbabka ee dumarka iyo kansarka sanbabada ee ragga. Waxaan sidoo kale ognahay in unugyada kansarka sambabku ay leeyihiin qabtayaasha estrogen, taas oo ah, meelaha dusha sare ee unugyada ku xirnaado estrogen. Inkastoo aqoontayadu ay ka fog tahay waqtigan, maxay micnaheedu noqon kartaa tan macnaheedu in haweenka qaba kansarka sanbabada maanta, ama ay halis ugu jiraan kansarka sanbabada mustaqbalka?
Ka hor inta aanad ka hadlin daraasadaha, waxaa fiican inaad sharaxdo sababta natiijooyinka qaar ay noqon karaan kuwo jahawareer leh. Waxaa jira dhowr siyaabood oo kala duwan (qaababka) oo ay estrogen ka ciyaaraan doorka kansarka sanbabada. Waxa kale oo muhiim ah in la tilmaamo in badan oo ka mid ah daraasaddan ayaa ka hadlay laba arrimood oo kala duwan. Mid ka mid ah sababaha keena - heerka sare ama hoose ee estrogen ayaa saameyn ku yeelan kara haddii qof uu ku dhici doono kansarka sanbabada marka hore? Qalabka kale ee hormarisku wuxuu keeni karaa estrogen sababta kansarka sanbabada ee horay u jirey si uu u koro dhaqso ama u gaabiyo?
Taariikhda taranka
Inkastoo aan fahamsanahay in kansarka naasku uu aad ugu badan yahay haweenka bilaabaya in ay da 'yar yihiin da' da yar, cilmi baaristu ma aysan helin tan kaansarka sanbabada. Kansarka sanbabada waxaa loo maleynayaa in uu ka yar yahay haweenka haysta carruur ka badan kuwa ka yaryahay caruurta yar yar ama midkood, gaar ahaan haweenka weligood sigaar cabbin.
Qiimayn dhowaan ah ee cilmi-baarista ilaa taariikheed waxay soo jeedinaysaa in kansarka sanbabada unugyada yar-yar , laakiin aan ahayn kansarka sanbabada unugyada yaryar , ayaa laga yaabaa in ay yaraadaan waxoogaa yar oo dumarka leh carruur badan. Hal daraasad ayaa lagu ogaaday, in liddi ku ah kansarka naasaha, halista kansarka sanbabada ayaa yaraysay markii haweenku dhalaan da'da dambe.
(Marka la barbardhigo, kansarka naasku waxa la yareeyaa halista ugu horreysa ee ilmo yar oo hore (ka hor 30), laakiin halista kansarka sanbabada ayaa yareysa marka ilmuhu sii wato noloshiisa.)
Daraasad dhowaan soo baxday ayaa soo jeedisay in dumarka ay labadooduba ka saaraan ugxan-yari ("qalitaanka menopause") waxay halis u yihiin inay qaadaan kansarka sanbabada. Daraasadaha qaarkood waxay sidoo kale muujiyeen xidhiidh yar oo u dhexeeya menopause iyo horumarinta kansarka sanbabada.
Daraasaadka Xoolaha
Mid ka mid ah daraasad ku saabsan jiirarka ayaa soo jeediyay in estrogen uu kor u qaadi karo kansarka sanbabada. Daraasaddan, jiirarka haweenka ee lahaa ugxan-yari ayaa sameeyay buro badan oo sambabada ah oo ka badan jiirarka dumarka ah kuwaas oo lahaa ugxan-yari ayaa laga saaray. Intaa waxaa dheer, marka jiirarka aan lahayn ugxan-yare ayaa lagu daaweeyaa estrogen, burooyinkooda waxay ka soo baxeen jiirka oo aan lagu daaweynin estrogen.
Hormoon Kalkaalinta Hormoonka
Daaweynta hormoonada hormoonka isku-dhafan , ama HRT (estrogen iyo progesterone) ee calaamadaha menopausal waxay kordhin karaan halista dhimashada kansarka sanbabada, gaar ahaan dadka sigaarka cabba. Daraasad lagu sameeyay 16,000 oo haween ah oo qaba kansarka sambabada unugyada yaryar, kuwa isticmaalayay daaweynta hormoonka isku-dhafan ee isku-dhafan ayaa 60 boqolkiiba ay u badan tahay inay u dhintaan cudurka. Waxaa muhiim ah in la ogaado in daraasaddan, isku-dar ah HRT ay kordhisay khatarta dhimashada kansarka sanbabada haddii ay hore u qabeen, laakiin maaha fursada uu qofku ku dhici karo kansarka sanbabada.
Guud ahaan, daraasadaha eegaya isku-dhafan oo sabab u ah kansarka sanbabada ayaa isku dhafan, iyadoo qaar ka mid ah muujinayaan koror, qaar aan muujineyn urur, iyo daraasado cusub oo dhab ah oo muujinaya hoos u dhaca halista kansarka sanbabada.
Dib-u-eegista PLoS-ka ayaa eegay doorka daaweynta estrogen (iyada oo aan lahayn progesterone) oo kaliya halista kansarka sanbabada haweenka iyada oo qayb ka ah daraasadda California Teachers. Daraasaddan, wax urur ah (ma kordhin ama hoos u dhac) inta u dhexeysa isticmaalka daaweynta isku dhafan (estrogen plus progesterone) iyo halista kansarka sanbabada. Si kastaba ha noqotee, haweenka isticmaala daawada estrogen oo keli ah, dadka isticmaala hore ee estrogen oo leh mudo gaaban oo ah isticmaalka (in ka yar 5 sano) ayaa halis yar ugu jirta inay ka dhintaan kansarka sanbabada (46 boqolkiiba way ka yaryihiin), iyo kuwa isticmaala dhawaan estrogen oo leh waqti dheer Muddada isticmaalka (ka weyn 15 sano) ayaa sidoo kale halis yar u ah dhimashada cudurka (40 boqolkiiba ay ka yaryihiin).
Hal daraasad ayaa lagu ogaaday in uu ka hooseeyo kansarka sanbabada dumarka isticmaala kiniinka ka hortagga uur-qaadidda.
Phytoestrogens
Qaadashada estrogens-ku salaysan dhirta (phytoestrogens), sida kuwa laga helo soy, ayaa lagu eegay dhowr daraasadood oo la xiriirta kansarka sanbabada. Qaar ka mid ah kuwan, waxay u muuqataa in dumarka isticmaala cuntada sare ee phytoestrogen ay leeyihiin dhacdooyinka hoose ee kansarka sanbabada, gaar ahaan dumarka aan weligood sigaar cabbin.
Khadka hoose
Sababtoo ah kansarka sanbabadu waa siyaabo badan, cudur ka duwan haweenka, waxaa muhiim ah in la eego doorka suurtogalka ah ee estrogen. Laakiin sida kor ku xusan, waxa aan fahamsanahay qiyaasta estrogen iyo kansarka sanbabadu wali waa marxaladaha hore.
Nidaam kasta ama daaweyn kasta, aad ayey muhiim u tahay in la miisaamo faa'iidada daaweynta ee ka iman karta khatarta suurtogalka ah. Tusaale ahaan, haddii dhakhtarkaagu kugula taliyo in lagaa saaro ugxan-sidahaaga sababo yar awgeed, faa'iidada hawsha ayaa laga yaabaa inay aad uga badan tahay kororka suurtagalka ah ee qatarta kansarka sanbabada.
Hadda, daraasadahani waa xusuusin wacan inaad la hadasho dhakhtarkaaga haddii aad ku jirto daaweynta hormoonka beddelidda hormoonka, gaar ahaan haddii aad sigaar cabto, oo aad weydiiso su'aalo. Ma u baahan tahay inaad qaadato daawooyinka? Ma jiraan wax kale? Ma jiraan faa'iidooyin ka baxsan khatarta ka iman kara dhimashada sare ee kansarka sanbabada (ama kansarka naasaha)?
Qoraalka kama dambaysta ah, fahamka unugyada kansarka sanbabada leh hindhicirada estrogen ayaa furaya albaabada laga yaabo in laga yaabo in qaar ka mid ah daawooyinka loo isticmaalo si caadi ah ee kansarka naasku ay kaalin ku yeelan karaan daaweynta kansarka sanbabada mustaqbalka.
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