Salicylates waxaa lagu kala qeybiyaa NSAIDs
Kiimikada, salicylates waa cusbo ama ester salicylic acid. Badankeena waan ognahay in asbirin ay ka soo baxdo salicylic acid. Aspirin ayaa loo yaqaan 'acetylsalicylic acid'. Salicylates waxay u qaybsamaan laba kooxood, asal tirtiran iyo kuwa aan habeynin. Inkastoo aspirin uu yahay acetylated, tusaaleyaasha salicylates ee aan-ku-habeeynka ah waxaa ka mid ah Disalcid (salsalate), Trilisate (choline magnesium trisalicylate), iyo Pepto-Bismol (bismuth subsalicylate).
Mid kale oo loo yaqaan Dolobid (diflunisal), oo aan hadda laga helin Mareykanka.
Sidee loo Isticmaalaa Saladiin
Looga heley dhirro gaar ah, sida caleemaha cagaaran iyo caleemaha jiilaalka, salicylates ayaa la rumeeysan yahay in ay leeyihiin saameyn difaac ah oo ka dhan ah cayayaanka iyo cudurada dhirta. Sanadkii 1860, salicylic acid waxa loo isticmaalaa si kaamil ah oo keena isticmaalka baahsan. Daweyn, salicylic acid wuxuu leeyahay xanuunka (xanuunka-xannibaadda), anti-bararka, iyo hanti-gaboobo. Iyo, maxaa yeelay waxay xanibi kartaa xanuunka iyo sidoo kale yareyn kara barar iyo qandho, salicylic acid waxay u muuqatay sida Trifecta ee daawada. Si kastaba ha noqotee, qiyaasta loo baahan yahay si wax looga qabto jawaabta, salicylic acid waxay sababi kartaa dhibaatooyinka caloosha. Haddii la isticmaalo qadar ballaadhan, ka weyn wixii loo qoray daaweyn waxtar leh, salicylic acid waxay noqon kartaa sun. Waxaa intaa dheer, dadka qaarkood waxay xasaasiyad ka qaadi karaan salicylic acid. Marka laga reebo isticmaalka daawada, Salicylates waxaa loo isticmaalaa cuntada lagu ilaaliyo cuntooyinka, daawooyinka antiseptics, waxayna leeyihiin waxyaabo kale oo caawiya kahortaga korriinka bakteeriyada, dila fungus, iyo diirka maqaarka (keratolytic, sida Kerasol).
Khatarta Xinjirowga iyo Khatarta Wadnaha ee Isku Xirka Salicylates
Si ka duwan Aspirin, oo xakameysa tratelet agagaarkiisa iyo sidaas awgeed waxay kordhisaa khatarta dhiigbaxa, xeryahooda aan xakameynin waxay waxyeelleynayaan xinjiraha. Natiijadu, waxay u badantahay inay keenaan dhiigbax ama boogaha dhiigga ee qiyaasaha loo baahan yahay si loo yareeyo bararka iyo xanuunka arthritis.
Dhinaca kale, ugu yaraan marka la barbardhigo daawada asaasiga ah ee hooseeyo, ma jiraan wax baaritaan ah oo lagu taageerayo salicylates-ka nonacetylated noncetylated cardioprotective. Xaqiiqda, sida dhammaan NSAID-yada kale (daawooyinka nonsteroid anti-inflammatory) , isticmaalkooda waxay keeni karaan halis dheeraad ah ee dhacdooyinka wadnaha ee wadnaha, sida wadnaha wadnaha.
Sida laga soo xigtay rheumatologist, Scott J. Zashin, MD, "Haddii aan qaato daawada sare ee Aspirin waa sida iskood loo yaqaano" cardioprotective "sida dufanka hooseeya ee aan la baadhin, intaa waxaa dheer, aqoontayda, ma jirto daraasado la daabacay oo la barbardhigaya waxtarka iyo amniga caloosha salicylates aan saloketillada ahayn iyo COX-2 inhibitors . "
Daraasado laga heli karo quseeya salicylates waxay u muuqdaan kuwo da 'weyn. Daraasad lagu daabacay Jariidada Rheumatology waxay la barbar dhigtay waxtarka salsalate (salicylate aan salokolado ahayn) oo loo yaqaan " Voltaren" (diclofenac) . Waxaa lagu soo gabagabeeyay in salsalate iyo diclofenac ay si isku mid ah u shaqeynayeen iyo in salsalate loo tixgelin karo beddel kale NSAIDs kale.
Daraasad kale, oo sidoo kale lagu daabacay Jareerka Rheumatology, ayaa qiimeeyey saameynta da 'da ee salicylate toxicity ee dadka waayeelka leh rheumatoid arthritis . Inkastoo ay qaadatay qadar yar oo salicylate ah oo ka yar kooxda da'da yar ee daraasaddan, kooxda waayeelka ayaa lala xiriiriyay in ay kordhaan sunta.
Dr. Zashin wuxuu yiri, "Iyada oo ku saleysan waayo-aragnimadayda, NSAID-yada iyo COX-2 inhibitors waxay yihiin, guud ahaan, waxtar badan oo lagu daaweyn karo xanuunka iyo bararka arthritis-ka, taas oo la sheegay, tijaabo ah salicylate nonacetated ma aha macquul bukaanka la soo xulay oo leh halis dheeraad ah ee dhiig-baxa ama boogaha. "
Ereyga
Sanadihii hore, salicylic acid ama aspirin wuxuu ahaa daawada aasaasiga ah ee loo isticmaalo in lagu maareeyo xanuunka arthritis. Taasi waxay u muuqatay in la yareeyo caabuqa waxay ahayd abaalmarin wakhtigaas. Hadda, waxaa jira daroogo badan oo laga yaabo in ay doortaan. Guud ahaan waxay u arkaan in ay noqon karto mid ammaan ah, iyo sidoo kale qiimo jaban marka la barbardhigo daroogooyinka kale, Salicylates waa ikhtiyaar ay tahay in ay tixgeliyaan dhakhaatiirta iyo bukaanada.
Waxay macno u leedahay adiga iyo takhtarkaaga inay tixgeliyaan taariikhdaada caafimaad (sida, boogaha, cudurka wadnaha) markaad dooranaysid doorarka daawooyinka.
> Ilo:
> Bombardier C. et al. Salsalate, Salicylate A Nonetetated, Waa sida Diclofenac ah ee bukaanka qaba Rheumatoid Arthritis. Kooxda Daraasaadka-Diclofenac Salsalate-Diclofenac Wargeyska Rheumatology. 1995. Abriil; 22 (4): 617-24.
> Horumarinta RR et al. Salicylate Sun ah ee Bukaanada Dadka waaweyn ee qaba Rheumatoid Arthritis. Wargeyska Rheumatology 1987. Feb: 14 (1): 60-66.
> Salicylates. Drugs.com.