Rheumatoid Arthritis Bukaanka cilmi baarista Rituxan wuxuu kobciyay xaalad halis ah PML
Xaalad dhimasho ah oo ah PML (leukoencephalopathy) ayaa lagu ogaadey bukaanka rheumatoid arthritis-ka (RA) kaas oo ka qayb qaatay tijaabo caafimaad oo loogu talagalay Rituxan (rituximab). Sidaa awgeed, FDA iyo kuwa soo saaraha daroogada ayaa soo saaray digniin waxayna cusbooneysiin doonaan macluumaadka Rituxan oo ku saabsan macluumaadka qorista ee PML.
Maxay tahay PML?
PML waxaa kale oo loo yaqaannaa "leukoencephalopathy"
Sida uu qabo Machadka Qaran ee Cudurrada Dumarka iyo Istaroogga, "Horumarinta 'Leukoencephalopathy Multipurpose Multipocal (PML) waxaa sababay dib u soo noqoshada fayraska caamka ah ee nidaamka dhexe ee dareenka ee shakhsiyaadka difaaca jidhka ah Polyomavirus JC (badanaa lagu magacaabo fayraska JC) badankood dadka oo aan wax dhib ah lahayn marka laga reebo kuwa difaaca jirkoodu hooseeyo. "
Ma ka warqabaa bukaan-socodka RA ee soo saaray PML?
Bukaanka RA waxay markii ugu horaysay sameeyeen caabuq fayraska JC ah kadibna PML. Dhimashada PML ayaa dhacday 18 bilood ka dib markii bukaanku qaatay qiyaasta ugu dambeeysay ee Rituxan ee daraasadda kordhinta badbaadada.
Bukaan-socodka RA-da waxa kale oo uu sameeyay kansarka naas-nuujinta (kansarka dhuunta ) waxaana lagu daaweeyay kemotherabi iyo shucaac 9 bilood ka hor inta aan la samaynin PML. Bukaanku wuxuu lahaa taariikh nololeed oo adag oo daaweyn ah oo ka qayb qaadan kara horumarinta PML. Marka laga reebo RA, bukaanku wuxuu lahaa Sjogren's syndrome iyo heerarka dhamaystiran oo aan la ogaan karin C4.
Bukaanka waxaa lagu daaweeyaa daawada methotrexate, steroids, iyo TNF blocker ka hor inta aan lagu daaweyn Rituxan. Daaweynta methotrexate iyo steroids ayaa sidoo kale loo isticmaalay daaweynta rituximab ka dib iyo ka dib.
Maxay tahay FDA in ay ka jawaabto dacwada PML?
FDA waxay dib u eegaysaa tilmaamaha qorista iyo wargalinta xirfadlayaasha daryeelka caafimaadka ee warqad iyo dadweynaha boggooda internetka ku saabsan kiisaska dhimashada PML.
Maxay tahay in bukaanka RA-du loo Bixiyo Rituxan?
Sida had iyo jeer, kala hadal taxadarkaaga dhakhtarkaaga. Khabiiradu waxay ku talinayaan in haddii bukaanka lagu daweeyo Rituxan uu yeesho calaamadaha neerfaha - la-tashiga maskaxda, maskaxda MRI, iyo lumbar puncture waa in la tixgeliyaa. Bukaan-socodka hormariya PML waa in ay joojiyaan Rituxan, laga yaabee inay joojiyaan ama yareeyaan difaacayaasha kale ee difaaca, iyagoo tixgelinaya daaweynta anti-viral. Laakiin, dhab ahaantii ma jirto daaweyn lagu xalin karo PML haddii ay horumariso.
Ilaha:
FDA: Xaaladda Dhimashada ee Cudurka Kansarka ah ee Multifocal Leukoencephalopathy ee Patient Receiving Rituximab. Tilmaamaha Dhakhtarka . Sebtember 11, 2008.
FDA Medwatch. Macluumaadka Badbaadada Cusub ee Muhiimka ah ee Loogu Talagalay Horumar Dhaqameedka Multifocal Leukoencephalopathy Iyadoo Isticmaalka Rituxan. Sebtember 11, 2008.