Daawooyin kala duwan oo daawooyinka IBD ah Target TNF Proteins si loo daweeyo infakshan
Tumor necrosis factor (TNF) waa nooc ka mid ah borotiinka waraaqaha loo yaqaan 'cytokine' kaas oo soo saaray unugyada dhiigga cad . TNF waxay muhiim u tahay jirka sababtoo ah waxay ka caawisaa habeynta nidaamka difaaca jirka si shey shisheeye, gaar ahaan bukaanka kansarka ee hadda jira. Waxay kor u qaadaysaa caabuqa, waxay soo saartaa unugyo kale oo loo isticmaalo jawaab celinta, waxayna caawin kartaa unugyada bogsata.
TNF waxaa mararka qaarkood loo yaqaan 'necrosis factor-alpha.
Waa maxay sababta TNF-alpha muhiim u tahay IBD
TNF waa mawduuc muhiim ah oo lagu daaweyn karo cudurka mindhicirka bararka (IBD). TNF waxaa laga helaa xaddi badan dadka qaba cudurka Crohn marka loo eego dadka aan haysan cudurka Crohn. TNF waxaa sidoo kale laga helaa, heerka hooseeya, saxarada dadka qaba xameetida sambabada. Sababtoo ah ururkan, waxaa loo maleynayaa in TNF kaalin ka qaadato horumarka iyo / ama sii socota cudurka Crohn iyo colitis sambabada. Tani waa sababta daroogooyinka loogu yeero biologiska loo soo saaray si loo daaweeyo IBD iyo xaalado kale oo barar ah. Bartilmaameedka TNF wuxuu muujinayaa faa'iido bukaanjiifka ah oo yareynaya calaamadaha IBD iyo in uu bogsiiyo xuubka mindhicirka.
Cudurka 'Confecectin' iyo 'lactoferrin' waa laba calaamadood oo loo isticmaalo in lagu qiimeeyo infekshanka hadda ee dadka qaba IBD. Labadan borotiin ayaa lagu qiyaasi karaa baaritaanka saxarada.
Waxaa la ogaadey in marka ay jiraan wax badan oo ka mid ah borotiinnada ku jira saxarada, waxaa jira barar badan oo ka yimaada mindhicirrada dadka leh IBD. Marka qadarka borotiinnadani ay hooseeyaan saxarada, waxaa jiri lahaa bogsashada kaadida ee xiidmaha. Qadar-celinta calprotectin-ka iyo xaddiga lactoferrin ayaa macnaheedu noqon karaa in daaweyntu ay shaqeyneyso iyo in bukaanku soo dhowaado, ama uu ku jiro midabtakoor.
Cilmi-baaristu waxay muujisay in daaweynta calfotectin iyo lactoferrin ay hoos u dhacaan bukaanada kuwaas oo qaatay daawooyinka anti-TNF.
Noocyada kala duwan ee TNF
Daraasooyinka genetka ayaa muujiyay in ay jiraan noocyo kala duwan oo TNF ah, TNF waxaa loo tixgeliyaa "Baaxad weyn." Noocyo kala duwan oo TNF ah ayaa lala xiriiriyay cudurro gaar ah, iyo kansar, iyo sonkorow. Helitaanka noocyada TNF-la xiriirta xaalado gaar ah waxay gacan ka geysan kartaa horumarinta mukhaadaraadka si loogu daaweeyo cuduradaas.
Qof kasta oo IBD ka jawaab celiya maandooriyaha isla sidaas oo kale. Tani waxay noqon kartaa, waxaana hadda loo maleynayaa in ay tahay kiis khibrad leh, in ay jiraan waxyaalo badan oo ka mid ah IBD. TNF ayaa sidoo kale laga yaabaa inay tan door ka ciyaaraan, sababtoo ah dadka qaarkood ee IBD waxay si fiican uga jawaabaan daawooyinka TNF-ka ee ka hortagga, halka dadka kale aysan sameyn. Cudurka qaaxada ee TNF ee bukaan-socodka gaar ah waxaa laga yaabaa inay la xiriirto jawaab weyn ama ka yar wax ka qabashada daawada anti-TNF. Tani waa goob cusub oo cilmi baaris ah, waxaana jira wax badan oo la fahmi karo oo ku saabsan TNF ka hor inta aan lagu dabaqi karin daryeelka bukaanka.
TNF-alpha Kansarka Kansarka
TNF ayaa sidoo kale laga yaabaa inay door muhiim ah ka qaadato kansarka mindhicirka iyo kansarrada kale ee gastric. Cilmi-baarista kufadan TNF weli wali ma ahan mid cakiran, laakiin waxa kale oo laga yaabaa inay tilmaamo dhowr ah u gudbiso xidhiidhka ka dhexeeya coli boogta iyo kansarka mindhicirka.
Dawooyinka anti-TNF-alpha
Qaar ka mid ah daaweynta caafimaadka ee Crohn's cudurku waxay ku lug leedahay bar-tilmaameedka borotiinka TNF iyo qabashada. Marka borotiinku uu sidaas ku xiran yahay, ma awoodo inuu soo saaro infakshan. Qaar ka mid ah daroogada anti-TNF waa Remicade (Infliximab), Humira (adalimumab), Cimzia (certolizumab pegol), Enbrel (etanercept), iyo Simponi (golimumab).
Xusuusin ah
Waxaa weli jira wax badan oo aan la fahmin oo ku saabsan TNF iyo xiriirka xaaladaha xanaaqa sida IBD. Si kastaba ha ahaatee, daroogo dawo oo TNF ah ayaa loo sameeyay si loogu isticmaalo dadka qaba IBD, waxaana laga yaabaa inay soo hagaagaan natiijooyinka cuduradaas.
> Ilo:
> Sipponen T, Savilahti E, Kärkkäinen P, et al. "Fecal calprotectin, lactoferrin, iyo dhaqdhaqaaqa endoscopic ee ilaalinta daaweynta anti-TNF-alpha ee cudurka Crohn." Dareemo fareemo Dis. 14: 1392-1398.
> Subramaniam K, Richardson A, Dodd J, iyo al. "Saadaalinta hore ee xammuulka iyo daaweynta muddada-dheer ee raaxeysiga ee bukaanka colitis ee bukaanka ayaa daweeyey isticmaalka daaweynta necrosis-factor for anti-tumor." Interniga Med J. 2014 Maajo 44: 464-470. doi: 10.1111 / imj.12397.
> Taylor KD, Plevy SE, Yang H, et al. "Nidaamka ANCA iyo xidhiidhka laparoolka LTA ee jawaabaha caafimaad ee daaweynta anti-TNF antibody ee cudurka Crohn." Gastroenterology . 2001 May; 120: 1347-1355.
> Yang JP, Hyun MH, Yoon JM, iyo al. "Ururka u dhexeeya TNF-α-308 G / A hiddesidaha polymorphism iyo halista kansarka qandhada: waa dib-u-eegis nidaamsan iyo mala-dhaf." Cytokine . 2014 Dec; 70: 104-114. doi: 10.1016 / j.cyto.2014.07.005.