Maxay Tahay Sababaha Eosinophilia?

Dib u Eegista Sababaha, Diagnosis, iyo Daaweynta Eosinophilia

Eosinophilia waa magaca farsamada ee loo yaqaan 'eosinophil count'. Eosinophils waa nooc unugyada dhiigga cad oo burburiya walxaha jidhka sida parazit oo ka qayb qaata falcelinta xasaasiyadda.

Maxay Tahay Sababaha Eosinophilia?

Waxaa jira sababo badan oo lagu xoojiyo tirada eosinophil. Qaar ka mid ah sababaha ayaa ah mid wanaagsan oo u baahan daaweyn yar.

Maaha wax aan caadi ahayn in tirada tiradu sarayso ay noqoto mid joogto ah oo xalisa daaweyn la'aan. Aynu dib u eegno qaar ka mid ah sababaha hadda.

1. Caabuqyada noolaha: Dunida oo dhan sababaha ugu badan ee eosinophilia waa infekshan nool. Magacyada cudurradan waxaa ka mid ah schistosomiasis, trichinosis, xoogiloidiasis, iyo ascariasis. Naas-nuujintan waxaa laga heli karaa adduunka oo dhan oo ay ku jiraan Mareykanka. Taariikhda safarka waa qayb muhiim ah oo ka mid ah shaqo-helidda eosinophilia inkastoo maqnaanshaha socdaal la'aanta uusan ka talaabin infekshinada qatarta ah. Shubanka socdaalka ee loo yaqaan 'shuban' waa nooc ka mid ah infekshan nool, laakiin aan caadi ahaan la xiriirin eosinophilia.
2. Daawooyinka daroogada: Daawooyinku waxay kicin karaan eosinophilia, mararka qaarkood iyadoon wax calaamado ah ama astaamo ah. Daawooyinka ugu badan ee eosinophilia waxaa ka mid ah antibiyootiko (penicillin, cephalosporins), daawooyinka aan anti-inflammatory (aspirin, ibuprofen), ranitidine (for gastroophageal reflux), phenytoin (qallalka) iyo allopurinol (loo isticmaalo daaweynta gout). Nooca ugu daran waxaa loo yaqaana fal-celinta daroogada eosinophilia iyo calaamadaha nidaamka (DRESS). Nasiib wanaag, dadka intooda badan ma yeelan doonaan falcelintaan marka ay helaan daawooyinkan.

1. Atopy : Atopi waa falcelin gaar ah oo ka dhacda jirka. Caadi ahaan, neeftu waxay loola jeedaa neefta, xasaasiyadda xilliga (sidoo kale loo yaqaano "rhinitis"), iyo cambaar. Maaha wax aan caadi ahayn in qofku yeesho in ka badan hal xaalad caafimaad ee ay la xiriirto. Kuwani waa qaar ka mid ah sababaha ugu badan ee keena eosinophilia fudud, gaar ahaan carruurta. Sidoo kale, xasaasiyadda cuntadu waxay sidoo kale keeni kartaa eosinophil sarreysa.

1. Eosinophilia Eophagus (EoE): Tani waa cilad kudhaca eosinophils oo ku faafta casiraadda sida caadiga ah kuma jirto eosinophils. Qiyaastii 50% dadka EoE waxay sidoo kale ku leeyihiin dhiigga eosinophil.
2. Xanuunada hypereosinophilic: Hydroeosinophilic syndromes (HEP) waa koox xanuun ah oo lagu yaqaanno eosinophil aad u sarreeya iyo caddaynta dhaawaca xubnaha oo ka badan tirada eosinophils. Agagaaraha sida badan loo bartilmaameedsaday waa maqaarka, sanbabada, iyo mindhicirka. HES waxay noqon kartaa mid asaasi ah (oo sidoo kale loo yaqaanno neoplastic) secondary (reactive) ama idiopathic (sabab la'aan).
3. Churg-Strauss Syndrome: Churg-Stauss vaskulitis, oo hadda loo yaqaan eosinophilic granulomatosis leh polyangiitis, waxay sababi kartaa eosynophilia. Dadka qaba xaaladdan waxay la socdaan neefta iyo arimaha kale ee sanbabada marka hore, kadibna waxay sameeyaan eosinophilia, iyo ugu dambeyntii vasculitis , inflammation of xididdada dhiigga.
4. Kansarrada: Waxaa jira kansarro dhowr ah, gaar ahaan kansarrada dhiigga, kuwaas oo loo yaqaan in la kordhiyo tirada eosinophil. Kuwaas waxaa ka mid ah nooca nadirka ah ee 'myeloid leukemia' (AML) oo loo yaqaan 'eosinophilic leukemia'. Sababaha kale waxaa ka mid ah dhowr neoplasmallineed myeloprolative (sida, trombocythemia, vera polycythemia) B-cell iyo T-cell lymfoma, iyo sidoo kale adenocarcinomas ee mareenka caloosha iyo mindhicirka, sanbabada, iyo ilma-galeenka.

Waa Maxay Calaamadaha Eosinophilia?

Haddii aad leedahay eosinophilia, calaamadahaaga ayaa qayb ahaan lagu go'aaminaayo sababta keenta tirada eosinophilia ee sareeya. Haddii tirada eosinophil-ga aad u yar tahay, waxaa laga yaabaa inaadan lahayn astaamo. Calaamadaha caadiga ah waxaa ka mid ah:

• Finan
• Cuncun
• Shuban, marka laga hadlayo infekshanada dulinka ah
• Neefta
• Sanka oo furma, gaar ahaan haddii ay la xiriirto xasaasiyad.

Sidee loo yaqaan 'Eosinophilia'?

Sida cudurrada ugu badan ee dhiigga, eosinophilia waxaa lagu qeexay tirooyinka buuxa ee dhiigga (CBC) . Eosinophils waa mid ka mid ah unugyada dhiigga cad oo laga helo qaybta CBC oo la yiraahdo kala duwanaanta. Warbixinnada kala duwan intabadan noocyada unugyada dhiigga cad (nukologi, lymphocyte, monocyte, eosinophil, iyo basophil ) ayaa ku jira dhiigga.

Kadib markaad aqoonsato eosinophilia, bixiyahaaga daryeelka caafimaad ayaa bilaabi doona inaad ka shaqeysid si aad u aqoonsatid sababta, mararka qaarkoodna waxay u baahan tahay u gudbin dhakhtar kaadi mareenka. Nafaqada eosinophilia mararka qaarkood waxay u diri kartaa shaqada loo baahan yahay. Eosinophilia waxaa loo kala saari karaa tirada eosinophils (tirin eosinophil oo buuxa).

• Khafiif: 500 - 1500 unug / mL
• Dhexdhexaad: 1500 - 5000 unug / mL
• Daran:> 5000 unug / mL

Go'aaminta sababta eosinophilia-gaaga waxay ku saleysantahay calaamadahaaga. Eosinophilia ETofagiteri wuxuu sababi karaa liqidda liqidda, laabta iyo / ama calool xanuun, matag ama cunto ku dhejisey hunguriga. Cilad-baadhista waxay u baahan tahay dheecaan ka qaadista hunguriga. Qaar badan oo ka mid ah infakshannada noolaha ayaa lagu ogaadaa iyagoo qaadaya tijaabada saxarada waxayna tijaabiyaan. Ma jiri karto tijaabo si loo go'aamiyo haddii daawo uu sabab u yahay eosinophilia. Haddii tirakoobka eosinophil uu ku soo laabto caadi ka dib markii uu joojiyo daawooyinka, waxaa badanaa la aaminsan yahay in daawadu ay tahay sababta.

Maxay daaweyntu u kala duwan yihiin Eosinophilia?

Sidoo kale waxa loo baahan yahay in lagu ogaado nooca cudurka, daaweynta waxaa lagu go'aamiyaa sababta eosinophilia. Fursadaha waxaa ka mid ah:

• U fiirsasho: Haddii eosinophilia-yadaagu uu khafiif yahay, daaweynta shaybaarka lagu celiyo ayaa lagu talin karaa.
• Haddii daaweyntu keento tiradaada eosinophil-ta sareeya, waxaa laga yaabaa in la joojiyo
• In la kordhiyo daaweynta neefta, canbaarta, iyo xasaasiyadaha
• Caabuqyada noolaha waxaa lagu daaweeyaa dawooyinka ka hortagga udub-dhexaadka.
• Steroids sida prednisone waxaa loo isticmaali karaa in lagu daaweeyo cudurrada hypereosinophilic

Ereyga

Hypereosinophilia waa erey cabsi leh. Nasiib wanaag, dadka badankood ee qaba xaaladdan, waa mid deg deg ah waxayna u baahan tahay daaweyn yar. Qaar ka mid ah, ogaanshaha iyo daaweyntu waxay u baahan yihiin in loo gudbiyo takhasusle. Haddii aad qabtid walaac dheeraad ah, hubi inaad kala hadasho dhakhtarkaaga.

> Isha:

> Weller PF iyo Klion AD. Ku dhowaad bukaanka qaba eosinophilia aan la garanayn. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA.