Doorka Cannabinoids ee Daryeelka Kansarka
Cannabis sativa , oo sida badan loo yaqaan warshadda marijuana, waxay leedahay taariikh dheer oo daawo ah. Dhab ahaan, waxaa jira caddayn qoran oo ku saabsan isticmaalka xashiishadda ee cannabis ee Shiinaha oo la xidhiidha in ka badan 5,000 oo sano ka hor. Waxaa lagula taliyay cuduro kala duwan oo ka mid ah shubanka iyo dhiig-baxa si loo yareeyo laf-dhabarka iyo cufnaanta laabta, sidoo kale waxaa loo isticmaalaa sida "aphrodisiac", "pain-reliever", iyo suuxdin.
Maadaama aan ogahay jirkeena bini-aadanka iyo cudurrada, ayaa sidoo kale fahamkayaga daawooyinkan qadiimiga ah. Doorka nooca cannabis ah wuxuu ka ciyaaraa daaweynta maalinta casriga ah ee la yidhaahdo "leukemia" ama "lymphoma"?
Maxay yihiin Cannabino?
Cannabis sativa waxay soo saartaa in ka badan 70 kiimiko kiimiko oo loo yaqaan cannabinoids. Inkastoo 60 ka mid ah cannabinoids ay yihiin kuwo aan firfircooneyn oo waxoogaa saameyn ah ama wax saameyn ah ku leh shaqada maskaxdeena, xeryahooda haray waxay noqon karaan kuwo awood badan waxaana loo isticmaali karaa daaweyn si loo daaweeyo tiro calaamado ah.
Kuwa ugu awoodda badan ee cannabinoids waa tetrahydrocannabinol (THC) , wakiilka firfircoon ee marijuana. Helitaanka THC ee 1960-kii waxay keenaysaa horumarinta daawooyinka, dronabolol (Marinol), nabilone (Cesamet), Sativex, Levonantradol, iyo Synhexyl kuwaas oo ku saleysan qaababka dabiiciga ah iyo dabiiciga ah ee THC.
Sidee Cannabinoidku u shaqeeyaan?
Dhakhaatiirtu waxay soo qorayeen cannabinoids ka hor inta aanay xitaa garanayn sida dhabta ah ay u shaqeeyeen.
Tan iyo wakhtigaa, cilmi-baarayaashu waxay soo heleen laba qabqablayaasha jidhkeena oo cannabinoids ay ku dhaqmaan. Waxaa loo yaqaan 'cannabinoid receptor 1' (CB1) iyo cannabinoid receptor 2 (CB2).
CB1 waa daaweeye soo noqnoqota oo badanaa ku jira nidaamkayaga dhexe ee dareemayaasha kuwaas oo door ka ciyaara lallabbada, matagidda, iyo walbahaarka, waana kan saameynaya cannabis iyo THC.
CB2 waxaa laga helaa unugyada kale ee jidhka waxayna ka ciyaaraan doorka difaaca jirka .
Cannabinoids waxay kiciyaan kuwa soo dhaweeyaa, taas oo ugu dambeyntii keenta calaamadaha.
Maxay Cannabino?
Xilligan, cannabinoids ayaa loo ogolaaday isticmaalka bukaanka kansarka leh lallabbo iyo matag aan wax ka qabin daaweynta caadiga ah , iyo sidoo kale inay kiciyaan rabitaanka cuntada ee bukaanka AIDS / HIV. Daraasadaha cilmi-baarista ee kiniisadda ayaa si kastaba ha ahaatee muujiyay in daaweynta cannabinoid ay waxtar u leedahay in la maareeyo tirada calaamadaha bukaanka kansarka:
- Murugo
- Walaaca
- Xanuun
- Miisaanka culus
- Hurdada xun
Intaa waxa dheer, daraasado ayaa la socdaa si loo ogaado haddii daawooyinka saameynaya qabtayaasha CB2 (difaacu) inay dhab ahaantii dilaan unugyada kansarka.
Waa muhiim in la aqoonsado in daaweynta cannabinoid aysan u shaqeynin qof kasta, iyo in mararka qaarkood saameynta xun ee ka iman karta faa'iidada daroogada. Haddii aad la kulanto lallabo iyo matag aan la xakamayn karin, ama aad u maleyneyso inaad ka faa'iideysan karto daaweynta cannabinoid, la hadal dhakhtarkaaga.
Saameyn Sidee Loogu Fili Karaa?
Sida daawooyinka kale, cannabinoids waxay sababi kartaa dhowr waxyeelood oo soo raaca:
- Qabsashada
- Jahwareer
- Cadaadiska dhiigga ee hooseeya
- Afka qalalan
Qaar ka mid ah bukaannada qaata dronabinol waxay la kulmi karaan "sare" oo la mid ah dareenka la socda marijuana sigaarka.
Dhibaatooyinka dhinaca xun ee cannabinoids waxay badanaa la xiriiraan qiyaaso sarreeya waxayna yareyn karaan markaad sii wado.
Sidee Cannabino loo Qaadaa?
Inta badan cannabinoids waxaa lagu qaataa afka kiniinka ama kidharka. Tallaabooyinka daawooyinkani waxay qaadan karaan wakhti yar si ay u bixiyaan gargaar, sidaas darteed haddii aad qaadato daawooyinkan adigoo riixaya xanuunka ama lallabbada, waxaad u baahan doontaa inaad joogtid jadwal caadi ah oo aanad sugin calaamadahaaga si ay uga baxaan xakameynta ka hor it.
Sativex, oo ah 50/50 oo isku-dhafan THC iyo sidoo kale cannabinoid kale oo loo yaqaan cannabidiol, waa dareeraha lagu buufiyo afkaaga ama gudaha dhabarkaaga.
Bilawga ficilka Sativex ayaa ka dhaqso badan noocyada kale ee cannabinoids.
Maxaa ku saabsan Marijuana?
Marka daawooyinka cannabinoid lagu sameeyo shaybaarka, waxaa la sameeyaa si ay ula kulmaan tilmaamaha shuruucda caalamiga ah ee adag. Shuruudahaan waxay kaa caawinayaan hubinta in dhamaadka alaabtu uu yahay mid ammaan ah oo hufan. Iyadoo ku xiran hadba sida ciddii cannabis ah u kori lahayd, marijuana way ka duwanaan kartaa dufcadda si ay u noqoto mid soo noqnoqota oo aan loo raacin tilmaamaha badbaadada. Marka laga soo tago walaac kasta, tani waxay kor u qaadi kartaa waxtarka waxtarka leh ee sheyga, waxaa jiri kara tiro kasta oo ka mid ah waxyaabo aan nadiif aheyn taas oo horseedi karta waxyeello xun ama caabuq haddii la neefsado.
Marka laga reebo meelo badan oo sharci darro ah, sigaarka marijuana wuxuu u horseedi karaa cuncun sambabada, iyo, sida laga soo xigtay cilmi baarista, waxay sababi kartaa kansar .
Soo-soo-kabashada
Inkasta oo marijuana caafimaadku uu caan ka noqday warbaahinta dhowrkii sano ee la soo dhaafay, cannabis sativa ayaa loo isticmaalay daryeelka bukaanka muddo kumanaan sano ah. Markaan wax badan ka ogaanno faa'iidooyinka qaar ka mid ah xeryahooda ku jira xashiishka, aqoonyahaniintu waxay ku dadaalayaan in ay joojiyaan oo ay u nadiifiyaan kiimikooyinkaas si ammaan ah.
Ilaha
Guy, G., Stott, C. "Horumarka Sativex-dawada dabiiciga ah ee xashiishadda ku jirta" ee Mechoulam, R. (ed) (2005) Cannabinoids oo loo yaqaan 'Therapeutics Birkhauser Verlag': Basel, Switzerland. (pp. 231- 263).
Hanus, L., Mechoulam, R. "Chemistry of Cannabinoid: muuqaal guud" Mechoulam, R. (ed) (2005) Cannabinoids oo loo yaqaan 'Therapeutics Birkhauser Verlag': Basel, Switzerland (pp. 23- 46).
Musty, R. "Cannabinoids iyo walaac" oo ku yaal Mechoulam, R. (ed) (2005) Cannabinoids oo loo yaqaan 'Therapeutics Birkhauser Verlag': Basel, Switzerland. (pp. 141-147).
Bocelli, M., Ligresti, A., Di Marzo, V. "Isticmaalka suuska cannabimimetics ee daaweynta kansarka" ee Mechoulam, R. (ed) (2005) Cannabinoids sida Therapeutics Birkhauser Verlag: Basel, Switzerland. (pp. 165- 181).