Ka hubi xirfadlahaaga Gastroenterist ka hor intaadan qaadin qof xanuunsan
Waxaad eegtaa inta kudhowaad golaha dawooyinka oo aad u badan tahay inaad heshid NSAID (daroogada aan anti-inflammatory ahayn). NSAIDs, oo loo isticmaalo daaweynta xannuunka iyo bararka, ayaa caadi ahaan ah caan ku ah inay badanaa haystaan ​​xannibaadahooda u gooni ah ee daawooyinka. Xaqiiqdii, waa in la daryeelaa si loo hubiyo in dadku aysan si shakhsi ah u qaadanin NSAIDS badan, gaar ahaan sababta ay u sahlanaato in ay isticmaasho in ka badan mid ka mid ah daawooyinka bukaanka laga soo iibsado si loo daweeyo xanuunka iyo xummadda laga qaado hargabka ama kuwa kale jirro.
Isticmaalka kale ee NSAIDs waxaa ka mid ah daweynta madax-xanuun, murqo-xanuun, caadooyinka caadada iyo xannuun-maalmeedka iyo xanuunka.
Dadka qaba cudurka mindhicirka ee caabuqa (IBD) waxay dareemaan xanuun iyo xanuun sida qof kale. Qaar badani waxay sidoo kale dareemaan xanuun maalin kasta sabab u ah xaalado dheeri ah sida xinjirowga ama waxyeelada daroogada sida daaweynta madax xanuun. Hase yeeshee, qaar ka mid ah dhakhaatiirta gastroenteritis waxay ku taliyaan in bukaannadahooda IBD ay ka fogaadaan NSAIDs. Sababta: NSAIDs waxaa laga yaabaa inay saameyn xun ku yeeshaan cudurka Crohn iyo colitis-ka.
Sida NSAIDyadu u shaqeeyaan
NSAIDs waxay u shaqeeyaan iyaga oo xannibaya laba unug oo gaar ah oo jirka ku jira: cyclooxygenase-1 (COX-1) iyo cyclooxygenase-2 (COX-2) . COX-1 wuxuu ka ciyaaraa habka dheef-shiidka iyo COX-2 door ka ciyaaro geedi-socodka bararka. Hawsha COX-1 waa in la xakameeyo walxaha loo yaqaan ' prostaglandins' kaas oo ilaaliya weelka caloosha oo ka yimaada asiidhka ka caawiya inuu dheefshiido cuntada.
Prostaglandins oo ay soo saareen COX-2 waxay dhexdhexaadiyaan geedi socodka bararka iyo jawaabta xanuunka.
Taas macnaheedu waa in iyadoo NSAIDs ay hoos u dhigto wareegga xanuunka iyo xanuunka, waxay sidoo kale keenaan habka dheef-shiidka in ay lumiyaan qaar ka mid ah walxaha ilaalinta caadiga ah. Tani waxay abuuri kartaa dhibaatooyin dheeri ah dadka horay u qabay barar, ama suurtogalnimada caabuq, habka dheef-shiidka.
NSAIDs iyo Ulcers
Xitaa dadka aan haysan IBD, NSAIDs waxay ka qayb qaadan karaan boogaha labadaba caloosha iyo qaybta hore ee mindhicirka yar ( duodenum ). NSAIDs waxay keeni karaan caabuq iyo ka sii daraan dhiigbaxa mindhicirka yar. Qaar ka mid ah takhaatiirta dheef-shiidka ayaa ka walaacsan in NSAIDs ay keeni karaan IBD inay ka soo baxaan dib-u- dhiska .
NSAIDs iyo IBD
Cilmi-baaris ku saabsan in NSAIDs ay ku biiraan calaamadaha IBD waa isku dhac, abuurista muran ku saabsan adeegsigooda dhexdooda ka mid ah dhakhaatiirta gastroenteritis. Qeybta daawooyinka loo yaqaan 'COX-2 inhibitors', ma jiraan wax caddayn ah oo ku saabsan saamaynta ay ku leeyihiin dadka qaba IBD. Cilmi-baarisyada qaarkood waxay muujinayaan in NSAIDs ay saameyn karaan keliya boqolkiiba dad gaar ah oo leh IBD, laakiin ma'aha suurtagal in la ogaado cidda ay saamaynayso iyo kuwa aan ahayn. Waxaa la qiyaasey in isticmaalka COX-2 inhibitor, halkii uu ka ahaan lahaa daroogada labadaba COX-1 iyo COX-2 inhibitor, waxaa loo isticmaali karaa taxaddar kuwa kuwa IBD ku jirey xasilooni.
Dadka qaba IBD waa inay la tashadaan dhaqtarkooda gaasta ka hor inta aysan qaadanin NSAIDs, xitaa kuwa laga helo miiska. Sidoo kale aad bay muhiim u tahay in dhammaan xubnayaasha kooxda daryeelka caafimaadka ee bukaan socodka ay ka warqabaan saameynta NSAIDs ay ku yeelan karaan IBD.
Maxaa Loogu Heli Karo IBD
Dadka haysta IBD kuwaas oo raadinaya xannuun-ka-soo-kabashada oo laga yaabo in laga yaabo inay ka fikiraan acetaminophen.
Acetaminophen, oo lagu iibiyo magacyo fara badan, oo ay ku jiraan Tylenol, ma aha NSAID waxaana laga yaabaa inay noqoto door wanaagsan oo loogu talagalay dadka qaba IBD kuwaas oo u baahan xanuunka xasaasiga ah. Sida acetaminophen u shaqeynayo si loo xakameeyo xanuunka lama fahmo, laakiin waxaa loo maleynayaa in ay ku lug leedahay joojinta abuurista prostaglandins.
Had iyo jeer waydiiso in lagu daro liiska dawooyinka cusub, gaar ahaan kuwa loo isticmaalo in lagu maareeyo xanuunka. Ma aha xirfadle daryeel caafimaad kasta oo ka warqabta xidhiidhka suurtogalka ah ee ka dhexeeya xanuunka dawada iyo IBD. Marka dadka qaba IBD ay qaadanayaan qalliin ama nidaamyo, waxaa muhim ah in lagu dhajiyo dhaqdhaqaaqaha dhakhtarka gaasta si uu uga doodo xanuunka xanuun joojinta si loo hubiyo inaad haysato macluumaadkii ugu danbeeyey ee ku saabsan NSAID-yada iyo sida ay kuugu adeegsanayaan.
Hoos waxaa ku qoran jadwalka NSAID-yada oo ay bixiso warqad dhakhtar ama warqad dhakhtar. Tani micnaheedu ma aha liis dhamaystiran, markaa fadlan la tasho farmashiist ama takhtar walaac ku saabsan daroogooyinka gaarka ah.
Maandooriyeyaasha Lidka-Xakamaynta ee Aan Cudurka ahayn (NSAIDs)
| Magaca Brand | Magaca Guud |
| Advil, Excedrin IB, Genpril, Haltran, Ibuprin, Ibuprohm, Ibu-Tab, Midrin 200, Medipren, Midol IB, Motrin, Nuprin, Pamprin-IB, Rufen, Trendar | Ibuprofen |
| Aleve, Anaprox, Naprosyn | Naproxen Sodium |
| Amigesic, Anaflex 750, Marthritic, Mono-Gesic, Salflex, Salsitab, Disalcid | Salsalate |
| Anacin, Bayer, Bufferin, Ecotrin | Salicylate Choline |
| Ansaid, Froben | Flurbiprofen afka |
| Apo-Keto, Orudis, Oruvail, Rhodis | Ketoprofen |
| Apo-Sulin, Clinoril, Novo-Sundac | Sulindac |
| Aspergum, Genuine Bayer, Bayer Childrens, Bufferin, Easprin, Ecotrin, Empirin, Genprin, Halfprin, Magnaprin, ZORprin | Aspirin |
| Butazolidin | Phenylbutazone |
| Cataflam, Voltaren | Nidaamka Diclofenac |
| DayPro | Oxaprozin |
| Dolobid | Dhexdhexaad |
| Feldene, Novo-Pirocam, Nu-Pirox | Piroxicam |
| Indocin SR, Indocid, Novo-Methacin | Indomethacin |
| Lodine | Etodolac |
| Miisaaniyado | Isku-dhafka Sodium |
| Mobic | Meloxicam |
| Nalfon | Fenoprofen Calcium |
| Ponstan, Ponstel | Cuntada isku dhafan |
| Xiriir | Nabumetone |
| Tolectin | Tolmetin Sodium |
Ilaha:
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Sandborn WJ, Stenson WF, Brynskov J, et al. "Badbaadinta Celecoxib ee Bukaan-jiifka leh Cudurka Ulcerative Colitis ee Ka Saarista: Hab-raaca-Dhex-dhexaadinta, La-xakameyn, Diyaargarowga Duulista." Clin Gastroenterol Hepatol 2006 Feb; 4: 203-2011.
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Takeuchi K, Smale S, Premchand P, et al. "Daaweynta iyo farsamada daaweyn aan loo baahnayn oo daaweyn ah oo aan dawo lahayn oo dib-u-kicinaysa bukaan-socodka oo leh cudurrada caabuqa caabuqa." Clin Gastroenterol Hepatol . 2006 Feb; 4: 196-202.