Niacin (nicotinic acid) waa daawo dufan oo hoos udhaca oo saameyn kara dhamaan qaybaha kala duwan ee astaamahaaga , Dhab ahaan, daraasaduhu waxay muujiyeen in nicotinic acid ay:
- Kordhinta heerka HDL illaa 25%
- Kolestaroolka hoose ee LDL ilaa 35%
- Triglycerides hooseeya ilaa 50%
Inkasta oo aad ka heli karto niacin-nissin sii-dheer sii deynaya adigoo rijeeto qoraya, waxaa jira qaabab kale oo niacin ah oo la heli karo iyadoon warqad dhakhtar ah laguu qorin oo aad u jaban.
Inkastoo niacin aysan u baahnayn booqasho bixiyahaaga daryeelka caafimaadka rijeetada, tani macnaheedu maahan in ay tahay mid gebi ahaanba ammaan ah. Daraasad hore oo ballaadhan (AIM-HIGH study) ayaa shaaca ka qaaday in shakhsiyaadka qaba cudurrada wadnaha iyo xididdada loo yaqaan 'niacin' ay kordheen heerarka HDL - laakiin ma aysan arkin hoos u dhaca khatarta ay ku yeelan karaan dhacdooyinka wadnaha - sida istaroogga ama wadnaha wadnaha - ama dhimasho. Xaqiiqdii, wax isbeddel ah laguma xusin shakhsiyaadka daraasaddan iyagoo qaadanaya statin iyo niacin oo ka soo horjeeda dawladnimada. Intaa waxaa dheer, shakhsiyaadka qaadaya nicotinic acid ee daraasaddan waxay ku dhaceen dhacdooyin ka sarreeya istaroogga iskubuuqa. Sababtoo ah xaqiiqda ah inaysan jirin wax isbedel ah oo halis ah dhimasho ama dhibaatooyin ka yimaada cudurada wadnaha iyo walaaca ku saabsan kororka kufsiga isqoynta, baarayaashu waxay joojiyeen daraasaddan horaantii.
Dhibaatooyinka caanka ah ee lagu garto niacin waxaa ka mid ah maqaarka dushooda, lallabbo, nabaro kulul, iyo wadne garaaca wadnaha.
Si kastaba ha noqotee, waxyeelo kale oo halis ah ayaa sidoo kale dhici karta, waxaana la kordhin karaa haddii aad haysato mid ka mid ah xaaladaha caafimaad ee soo socda:
- Gout - Niacin waxay kordhin kartaa heerarka uric acid, kordhinta fursadahaaga inaad la kulantid weerar qoto dheer.
- Sonkorowga - Cudurka sokorowga ee niacin wuxuu ogaan karaa korodhka heerarka sonkorta dhiigga ee soonka.
- Cudurka boogaha Peptic - Daraasado lagu baarayo isticmaalka nicotinic sii-deyn la sii daayo ayaa soo tebiyey warbixinno horumarin boogta ah. Farsamooyinka ay tani dhacdo lama garanayo.
- Cudurka beerka - Qaadashada niacin wuxuu sababi karaa koror ku yimaada unugyada beerka, taas oo noqon karta mid aad u sareeya oo shakhsiyaadka hore loogu arkay cudurka beerka.
- Cudurka kelyaha - Qalitaanka kelyaha oo liita wuxuu keeni karaa niacin inuu ku ururiyo dhiigaaga, suurtogalnimada saameynta sunta.
- Uurka - Looma helin daraasado kugu filan si aad si habboon u qiimeyso badbaadada niacin ilmahaaga. Sidaa darteed, waa inaad la tashataa takhtarkaaga haddii aad uur leedahay, ama qorsheyneysid inaad uur yeelatid.
- Naasnuujinta naaska - Daraasaduhu waxay muujiyeen in niacin ay ka soo baxdo caanaha naaska, si kastaba ha ahaatee, si buuxda looma ogeyn haddii qiyaasaha la siiyay kolesteroolka hoose uu sidoo kale waxyeelo u geysan karo ilmaha.
- Cudurka wadnaha iyo xididada - Ka qaadashada niacin waxay ka sii dari kartaa xaaladaha wadnaha ee wadnaha, sida angina aan xasilloonayn.
- Xanuunada dhiigbaxa - Qaadashada alaabta niacin waxay yareyn kartaa awooddaada inaad xinjirto - oo kordhi kartid awoodaada dhiigga. Tani waxay sidoo kale dhici kartaa haddii aad qaadaneysid daawada xinjirowga lidka ku ah, ama "dhiig karlayaasha", sida Coumadin (warfarin) ama aspirin.
Daraasadaha, qaar ka mid ah shakhsiyaadka qaadaya niacin waxay ku talinayaan hoos u dhigista qiyaasta ama waxay keentay in niacin la joojiyo sababtoo ah dhibaatooyinka soo raaca.
Sababtoo ah saameynaha qatar ah ee halista ah iyo faa'iido la'aanta caafimaadka ee wadnaha, niacin laguma talinayo in daawo la qaato haddii aad rabto inaad hoos u dhigto heerarka lipid. Niacin waxay u badan tahay in la tixgeliyo bixiyahaaga daryeelka caafimaadka haddii aadan awoodin inaad si buuxda u xakameyso heerarka lipid daawooyinka kale - sida qaadashada statin oo kaliya ama midabada statin iyo ezetimibe.
Sidaa darteed, haddii aad raadineysid inaad ku darto niacin-gaaga hooseeya ee hoos u dhaca, kala hadal bixiyahaaga daryeelka caafimaadka marka hore. Isaga ama ayada ayaa laga yaabaa in ay leeyihiin siyaabo kale oo si ammaan ah hoos loogu dhigo heerarka baruurta iyo triglyceride, waxaana laga yaabaa inay dib u eegaan niacin haddii daaweynta kale aysan shaqaynayn.
Ilaha:
Micromedex 2.0. Truven Health Analytics, Inc Greenwood Village, CO Waxaa laga heli karaa: http://www.micromedexsolutions.com. Abaalmarinta Febraayo 10, 2016
Dipiro JT, Talbert RL. Farmashoterapi: Habka Pathophysiological, 9th ed 2014.
Baarayaasha AIM-HIGH. Niacin ee bukaanada leh heerarka HDL ee hooseeya ee kolestaroolka iyo helitaanka daaweynta degdegta ah ee daweynta. N Eng J Med 2011; 365: 2255-2267.
Stone NJ et al. Tilmaamaha ACC / AHA ee ku saabsan daaweynta kolestaroolka dhiigga si loo yareeyo halista halista wadnaha ee dadka qaangaarka ah. Wareegga 2014; Gudbinta 129 (25 Qalabka 2): S1-45