Tijaabooyinka Koowaad ee Lagu Sameeyay Marka Rheumatoid Arthritis la Sheegay
Calaamadaha rheumatoid waa macquul ah (caadi ahaan IgM) oo ku xiran gobolka Fc ee difaaca IgG. Awood-siintu waa borotiino ay soo saaraan habka difaaca jidhka , laakiin halkii ay weeraraan walxaha shisheeye, waxay ku weeraraan unugyada jirka. Haddii dhakhtarkaagu uu ka shakiyo inaad qabtid rheumatoid arthritis-ka , tijaabada baaritaanka rheumatoid-ka wuxuu hubaal ahaan ka mid noqon doonaa baaritaanada ugu horreysa ee lagu ogaanayo cudurka.
Baaritaanadii hore (tijaabooyinka) si ay u soo jeediyaan in macquulnimada astaamaha la xidhiidha rheumatoid arthritis ayaa lagu sameeyay 1940-yadii. Hore, kuwan waxay ahaayeen baadhitaano agglutin ah kaas oo serum ka yimid bukaanka rheumatoid arthritis-ka lagu muujiyay inay sababeen qulqulka unugyada dhiigga cas ee lafdhabarka ah ee la dareemay difaaca bakteeriyada lafa-beelka ah ee lafaha. Waxaa jiray isbeddello dhowr ah oo lagu sameeyey tijaabada asalka ah ee agglutinimada, ugu horreyntii bedelay ganaaxyada caleenta IgG-ku xiran ee unugyada idaha. Ugu dambeyntii, tijaabada 'ELISA' (baaritaanka immunosorsing immunosorbent enzyme-linked) ee loo yaqaan 'rheumatoid factor' ayaa la sameeyay, iyo sidoo kale baaritaanada nephelometry.
Baaritaanada agglutination, dhufashada ayaa muujinaya natiijo wanaagsan. Kala saaridda noocyada kala duwan ayaa laga samayn karaa tijaabada tijaabada si loo ogaado tayada. Qalabka tilmaanta ayaa muujinaya inta muunada la tirtiri karo ka hor inta aan roodhada laf dhabarta aan la garan karin (ma xoqin).
Baaritaanada nephelometry, sambal dhiig ayaa lagu qasi karaa unugyada difaaca si ay u sababaan isku dhejinta.
Iftiin ayaa loo maraa sambalka si loo ogaado heerka daruurta.
Fahmidda Natiijooyinka
Caadi ahaan, heerka caadiga ah ee baaritaanka rheumatoid factor waa la soo sheegay:
- In ka yar 40-60 a / mL
- In ka yar 1:80 (titer)
Fiiro gaar ah: Shaybaarada kala duwan way ku kala duwanaan karaan habka imtixaanka ama qalabka tijaabada ee loo isticmaalo, markaa raac natiijooyinka iyo inta caadiga ah ee ay bixiso sheybaarkaaga gaarka ah.
Natiijooyinka tijaabada baarista rheumatoid-ka ayaa jahwareer ku noqon kara bukaanka arthritis. Marka ugu horeysa, waxa ugu muhiimsan ee la ogaanayo waa in baaritaanka rheumatoid factor waa hal cutub oo macluumaad ah oo loo isticmaalo si loo soo saaro ogaanshaha. Ciladda gebi ahaanba waa mid ku salaysan natiijada baarista rheumatoid factor. Halkan waxaa ku qoran xaqiiqooyin kale oo lagama maarmaan ah oo ku saabsan baaritaanka rheumatoid factor oo ah inaad ogaato:
- Ciladda rheumatoidku waxay u fiicnaan kartaa dadka caafimaadka qaba (1% dadka yaryar iyo ilaa 5% kuwa ka weyn 70 sano).
- Ciladda rheumatoidku waxay noqon kartaa mid ku haboon cudurada kale ee rheumatoid-xanuunada iyo xaaladaha (sida infekshannada, kansarka) ama xaaladaha rheumatiska aan ka ahayn rheumatoid arthritis (sida, Sjogren's syndrom ama lupus ).
- Calaamadaha rheumatoid-ka waxaa lagu ogaan karaa dhiigga illaa 10 sano kahor inta aan calaamadaha cudurka rheumatoid ee arthritis ay muuqdaan. Si kastaba ha noqotee, hal kooxo hoose oo ka mid ah bukaanka rheumatoid arthritis-ka, rheumatoid factor waa la ogaan karaa marka calaamaduhu muuqdaan.
- Bukaannada rheumatoidka arthritis ee qaba cudurka rheumatoid (seropositive) waxay u muuqdaan inay qabaan cudur aad u daran, halka bukaanada diidmo u leh cudurka rheumatoid-ka (seronegative) ay yeeshaan xanuun yar iyo lafaha yar.
- Qiyaastii 20% dadka lagu sheego cudurka rheumatoid arthritis ayaa ah mid aan fiicnayn ee rheumatoid ah inta lagu jiro muddada cudurkooda.
Kliinikada kuhaboon ee Natiijooyinka
Natiijada baaritaanka natiijada rheumatoid-ka ee horayba u jirtaa waxay noqon kartaa mid wanaagsan, hase yeeshee xaqiiqda bukaan-socodka ee xaqiiqadaas wali waa su'aal. Sida laga soo xigtay Scott Zashin, MD, oo ah cilmi-baadhiste ka soo jeeda Dallas, Texas (scottzashinmd.com) iyo qoraaga Arthritis Without Pain - Mucjisada TNF Blockers iyo qoraaga buugii labaad ee Daaweynta Xuubka " Arthritis Treatment ", "Rheumatologistada caadi ahaan ma raacaan rheumatoid Marka la sheego baaritaanka rheumatoid arthritis-ga , in la yiraahdo, waayo-aragnimadayda, heerka isugeynta rheumatoid-ku wuxuu wax ka bedeli karaa dhaqdhaqaaqa cudurrada , laakiin taasi maaha mid caafimaad ahaan u adeegsanaya tijaabooyin kale, sida heerka masiibada foosha , protein (reactive protein) (CRP) , iyo mararka qaarkood calaamado kale oo laga yaabo in laga helo baaritaanada VECTRA , oo loo isticmaalo in lagu qiimeeyo dhaqdhaqaaqa cudurka Rheumatoid arthritis. "
Ilaha:
Kelley ee buugta qoraalka ee Rheumatology. Ninth Edition. Hawlgallada Xanuunka Rheumatoid Arthritis. Cutubka 56aad: Felipe Andrade et al. p. 804.
Astaamo ku saabsan Cudurada Rheumatic. Saddex iyo tobnaad. Waxaa daabacay Arthritis Foundation. Cutubka 6. Xanuunka Arthritis-ka ee Rheumatoid. Calaamadaha Rheumatoidka. p. 126.
Ciladda Rheumatoid (RF). MedlinePlus. La cusboonaysiiyay 4/20/2013.
https://www.nlm.nih.gov/medlineplus/ency/article/003548.htm