Xopenex ma ka fiican Albuterol?
Xopenex (levalbuterol) waa daawo la neefsado oo loogu talagalay daaweynta calaamadaha neefta oo ba'an, oo ay ka mid yihiin qufac, xiiq, neefsashada oo gaabis ah iyo xabadka. Xopenex wuxuu u shaqeeyaa iyadoo la nasasiiyo muruqyada siman ee ku wareegsan sanbabada, badiyaa dhowr daqiiqadood oo qaadashada daawada. Xopenex waxaa loo heli karaa labadaba sida daawada neefsashada iyo sidoo kale foomka xalka lagu bixiyo mashiinka nebulizer .
Xopenex waa firfircoonida firfircoon ee albuterol (oo loo yaqaan R-albuterol ama levalbuterol). Qaababka kiimikada ee daawooyinka waxay u dhexeeyihiin sida isku dhafka muraayada indhaha (midka loo yaqaan ' rasemic mix'), kaliya hal foom oo ka mid ah daawooyinka firfircoon. Nooca aan firfircooneyn (oo loo yaqaan S-albuterol ama dextroalbuterol) maaha wax ujeeddo ah marka laga reebo in uu "helo habka" ee foomka firfircoon oo laga yaabo in uu gacan ka geysto saameynaha. Tani waxay ahayd ujeedada ay udub dhexaad u tahay Xopenex - si loo wanaajiyo hawsha albuterol iyada oo hoos loo dhigayo saamaynta daawada.
Xopenex ka wanaagsan Albuterol ee Neefta?
Maaha mid gebi ahaanba cad. Markii Xopenex loo hormariyay, baarista xayawaanku waxay soo jeedisay in S-albuterol uu sababay barar sambabada, taasoo laga yaabo inay sii xumaan karto neefta. Waxaa sidoo kale loo maleynaayay in sida badan ee albuterol ah (isku darka R iyo S-albuterol isomers), looxa S-albuterol wuxuu ku ururi lahaa sanbabada, wuxuuna keenayaa murqaha muruqyada siman ee ku wareegsan sanbabada, taas oo ka sii daraysa calaamadaha neefta .
Sidaa darteed Xopenex ayaa la filayaa inuu ka shaqeeyo sidii loo daaweyn lahaa astaamaha neefta marka loo eego cunsuriyada albuterol.
Daraasadaha hore waxay muujiyeen in Xopenex uu ku fiicnaaday daaweynta neefta ka baxsan albuterol, tan iyo markii loo baahnaa xopenex loo baahan yahay si loo xakameeyo calaamadaha neefta marka la barbardhigo qiyaasta albuterol. Tan iyo markii Xopenex uu yahay kala bar ka mid ah albuterol, mid ayaa filaya in nuska xaddiga Xopenex uu u dhigmaa laba jeer qiyaasta albuterol; hase yeeshee, daraasaddan ayaa soo jeedisay in hal-meelood hal meel oo ka mid ah qiyaasta daawada albuterol loo baahan yahay si loo gaaro natiijo isku mid ah markii la isticmaalayo Xopenex.
Tani waxaa loo maleynayaa in ay sabab u tahay la'aanta S-albuterol isomer ee Xopenex, oo ka shaqaynaysay R-albuterol isomer.
Si kastaba ha ahaatee, xogta dhow ee Xopenex, si kastaba ha ahaatee, oo ay weheliso muuqaal guud oo ku saabsan dhammaan xogta la heli karo, waxay soo jeedinaysaa in Xopenex uusan ka fiicnayn daaweynta neefta intii la filayay. Qiyaasta Xopenex ayaa loo baahan yahay si loo gaaro natiijo isku mid ah oo lagu daaweeyo neefta waxay u muuqaneysaa qiyaas ahaan hal nus, taas oo ah waxa la filayo maadaama ay ka kooban tahay isomer firfircoon (R-albuterol). Calaamadaha S-albuterol waxay u muuqdaan inay yihiin kuwo isdaba-joog ah, taasoo macnaheedu yahay in aysan u dhaqmin ama ka hor imaanin daaweynta astaamaha neefta.
Xopenex ma leedahay saameyn yar oo ka yar Albuterol?
Albuterol si fiican ayaa loo yaqaan in uu sababo waxyeelo soo gaara, oo ay ka mid tahay muruqyada muruqyada, boogteyn, carqalado iyo garaaca garaaca wadnaha. Daraasad hore oo ku saabsan Xopenex ayaa soo jeedisay in sababta oo ah daawo aad u yar oo loo baahan yahay si loo gaaro faa'iido isku mid ah albuterol, waxyeellooyin yar ayaa dhici doona. Intaa ka sokow, waxaa markii hore loo maleeyay in S-albuterol isomer ay ugu horreyntii mas'uul ka ahayd saameyn badan oo ka mid ah saamiga albuterol, sidaas darteed Xopenex, oo aan ku jirin s-albuterol isomer, wuxuu keeni karaa saameyno yar.
Cilmi-baarisyo dhowaan soo jeediyay, si kastaba ha ahaatee, in saameynaha saamiga ee Xopenex ay u dhigantaa albuterol maaddaama ay dhab ahaantii tahay r-albuterol isomer oo mas'uul ka ah saameynta daawada albuterol.
Xasaasiyadda S-albuterol waa faafin, taasoo macnaheedu yahay inaysan wax saameyn ah ku yeelanaynin. Xirmada xirmooyinka ee Xopenex waxay sheegaysaa in heerka saameynaha kor ku xusan uu u dhigmaa qiyaaso u dhigma qiyaasaha xopenex iyo albuterol.
Baro sida loo isticmaalo loona nadiifiyo qalabka daawada Xopenex .
Ilaha:
Xirmada xirmo ee Xopenex [PDF]. Shirkadda Sepracor. Lasoo gooyey Jannaayo 13, 2011.
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