Interferon waa daroogo isku dhejiya borotiinka jirka ee habka difaaca jirka u isticmaalo si loo burburiyo fayraska. Interferon pegylated waa qaab isbeddel ah ee daroogada kaas oo awood u leh in uu sii joogo jidhka oo dheer, kaas oo bixiya daaweyn fiican. Polyethylene glycol (PEG) ayaa lagu daraa interferon, habka loo yaqaan pegylation, oo loo isticmaalo noocyo kale oo daawooyin ah.
Laba nooc oo interferon pegylated ayaa la heli karaa waxaana loo isticmaalaa in lagu daaweeyo infekshanka Cagaarshowga C.
- Peginterferon alfa-2a: Sidoo kale waxaa lagu magacaabaa alfa-2a, magaca Pegasys.
- Peginterferon alfa-2b: sidoo kale waxaa lagu magacaabaa alfa-2b, magaca ganacsiga PegIntron.
Waxaa loo tixgeliyey daaweynta xulashada, oo loo isticmaalo ribavirin, oo lagu qoray liiska Daawooyinka Aasaasiga ah ee Ururka Caafimaadka Adduunka. Daaweynta HCV waxay badaleysaa ogolaanshaha Sofosbuvir (Sovaldi) iyo Simeprevir (Olysio) 2013-ka FDA. Daawooyinkan cusub iyo kuwa kale ee hubiya in ay raacaan ayaa laga yaabaa in ay ka soo baxaan peginterferons daaweynta la door biday.
Farqiga ugu weyn ee udhexeeya labadan interfiyoodh ayaa ku jira qiyaasta. Alfa-2a waxaa loo isticmaalaa qiyaasta isbuuc ee go'an. Alfa-2b waxaa loo isticmaalaa sida qiyaasta toddobaadlaha ah oo ku salaysan miisaanka bukaanka. Waxaa jira faraqyo kale oo ka dhexeeya labada daroogo, laakiin intooda badani waa farsamo waxaana isticmaala dhakhtarka qorista .
Tusaale ahaan, alfa-2a waxay leedahay nuugid joogto ah ka dib marka la isku duro waxaana lagu qaybiyaa inta badan dhiiga iyo xubnaha. Laakiin alfa-2b waxay leedahay nuugid degdeg ah iyo qayb ballaadhan oo jirka ah.
Kala duwanaanta Waxtarka
Ilaa Janaayo 2008, wax xog ah oo toos ah lama barbar dhigin labadaan dawo. Taasi waxay isbeddeshay daraasad cilmi baaris oo ballaaran oo loo yaqaan IDEAL iyo isbarbardhig kale oo daaweyneed.
Kuwani waxay bixiyaan natiijooyin xiiso leh kuwaas oo u ogolaan doona dhakhaatiirta inay faham dheeraad ah u yeeshaan daawooyinka cagaarshowga C ee joogtada ah.
Daraasada IDEAL - Wax-ku-oolka Khafiifinta ee Shakhsi ahaaneed ee Ka Qayb-Qaadashada Bedka ah ee Qiimaynta Lafdhabarka Beddelka ah ee Qiimaynta Daawada Interferon - Waxay ku lug lahayd 3070 shakhsi oo tijaabo ah oo la xaddiday. Waxay ka heshay waxtarka udhexeeya alfa-2a iyo alfa-2b in heerka jawaab celinta xannibaadda . Alpha-2a wuxuu lahaa heer ah 41% iyo alpha-2b wuxuu lahaa SVR 39%.
Laakiin kiiska lama xidhin. Laba daraasado oo dheeraad ah ayaa helay farqiga u dhexeeya labadii mukhadaraadka, oo leh alfa-2a guuleystaha cad cad 12% ka sarreeya SVR.
Daraasad kale oo ku saabsan 3518 bukaan ah oo ka kooban toddoba toddobaad oo tijaabo ah ayaa la helay natiijooyin fiican oo la helay alfa-2a, inkastoo ay soo saartey heer ka sareeya nutropenia. Nutropenia waa hoos u dhaca tirada unugyada dhiiga cad. Tani waa saameyn aan ahayn mid aan macquul ahayn, sida unugyada dhiigga cad ayaa ah qaybta ugu muhiimsan ee nidaamka difaaca jirka. Marka la yareeyo, waxaad noqon kartaa mid aad ugu nugul infekshanka oo aan awood u laheyn inaad la dagaallanto bakteeriyada iyo fayraska.
Natiijooyinkaas ayaa la filayaa in la tixgeliyo marka lagu talinayo daaweynta. Laakiin daweynta cusub ayaa laga yaabaa inay soo gasho peginterferons sida daaweyn loogu talagalay cagaarshowga C ee daba dheeraaday.
Kani waa nooca cilmi-baarista iyo horumarinta. Waxay ugu dambeyntii noqotaa in la barbardhigo labadaan mukhaadaraad maaddaama daaweynta cusub ee la dooran doono.
Ilaha:
Berenguer M, Wright TL. Cagaarshow C. In: M Feldman, LS Friedman, LJ Brandt (eds), Dhibaatada beerka iyo beerka, 8e . Philadelphia, Elsevier, 2006. 1701.
Cagaarshowga C FAQs for Occupational Health, Oktoobar 14, 2015. Xarumaha Xakamaynta iyo Kahortagga Cudurrada
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