Calaamadaha, faa'iidooyinka iyo saameynta daaweynta ee daaweynta
Phosphodiesterase-4-inhibitors (PDE4) sida Daliresp (roflumilast) waa nooc cusub oo daroogo ah oo loogu talagalay cudurka dabaysha ee joogtada ah (COPD ) iyo cudurrada kale ee sanbabada. Daroogooyinkaasi waxay ka shaqeeyaan sidii loo xakamayn lahaa bararka marinnada hawada ee dadka u adkeysanaya daaweynta caadiga ah. Daliresp (roflumilast) ayaa ah PDE4 oo kaliya ee lagu aqbalo Maraykanka.
Sidee Phosphodiesterase-4-Jawaab Qabta Shaqada
Daawooyinka sida Daliresp oo lagu xakameynayo saamaynta fosfoodiesterase 4, enzim kaas oo ka shaqeeya inuu jebiyo mecerle la yiraahdo adenosin monophosphate cyclone (CAMP) Natiijada korodhka cAMP (sababtoo ah in aan la jebin by phosphodiesterase 4) falalka si loo yareeyo bararka sambabada iyo waxyaabo kale.
Astaamaha COPD waa infakshan dabadheeraad ah, dadka qaba COPD iyo neefta ayaa badanaaba haysta kororka PDE4 oo ka qaybqaata cudurkan.
Marka la yareeyo inflammation, daawooyinka sida Daliresp ayaa yarayn kara sifooyinka xajmiga xajmiga ee COPD, oo hoos u dhigta dib-u-dhiska hawada.
Maxay Tahay Inhibitorada PDE4?
Iyada oo la kordhiyo heerarka cAMP iyo hoos u dhigidda barar, PDE4 celiyeyaasha waxay hoos u dhigi kartaa tirakoobka COPD iyo hagaajinta shaqada sambabada. Iyadoo la kordhinayo cAMP, waxay sidoo kale keeni karaan buro-boodh.
Waxaa muhiim ah in la ogaado in daroogooyinkan aysan dayactirin sanbabada, waxay u shaqeeyaan si ay u yareeyaan caabuqa ayna uga hortagaan waxyeello dheeraad ah iyo sii xumeeyso calaamadaha.
Shuruudaha Daliresp (Roflumilast) ayaa la isticmaali karaa
Shuruudaha Daliresp loo isticmaali karo waxaa ka mid ah:
- COPD
- Neefta
- Psoriasis
- Cudurka jahwareerka (Psoriatic arthritis)
Goorma Ayaa Ay Isticmaalaan?
Ka hortagga PDE4 sida Daliresp ayaa loo isticmaalaa in lagu hagaajiyo hawlgabka sanbabada dadka qaba COPD deggan oo u adkeysanaya daaweynta caadiga ah.
COPD waxay u muuqdaan inay ka faa'iideysanayaan dadka qaba boronkiitada daba-dheera leh ee leh cudurro badan oo sii xumaanaya .
Maadaama maan-dooriyeyaashu ka shaqeeyaan infekshanka joogtada ah, looma isticmaalo weerarada ba'an ee ku dhaca COPD ama neefta, laakiin halkii daryeel caafimaad oo joogto ah.
Si ka duwan sida burkinniillada la neefsado, Daliresp waa hal mar, daawo afka ah oo laga helay in lagu hagaajiyo hawlgabka sanbabada ee bukaannada lagu daaweeyo salmeterol iyo Spiriva (tiotropium).
Saameynta daawada PDE4 waxay u muuqataa inay kudheeraato corticosteroids.
Waxyaabaha kale ee saameynaya
Dhibaatooyinka ugu weyn ee daawooyinka PDE4 waxaa ka mid ah shuban, lallabo iyo madax xanuun. Waxay u keeni kartaa miisaan lumis ah, marka miisaanku waa in la kormeeraa inta lagu jiro daweynta waxaana sababay calaamadaha nafsaaniga ah dadka qaarkood.
Isdhexgalka
Cudurka macaanka ee "cytochrome P-450", daawada PDE4 way fara gelin kartaa (korodhsiin ama hoos udhac) daawooyinka kale ee sidan oo kale, sida daawooyinka sida erythromycin, cimetidiin, kiniinka ilaalinta dhalmada, dawooyinka qallalka, iyo wax kale.
Waxa kale oo loo yaqaanaa: PDE4, farsamooyinka fosfodiesterase-4 oo xaddidan
Ilaha:
Ferguson, G., iyo B. Samee. Maareynta daawada xasaasiyadeed ee xasiloon ee joogtada ah. UpToDate. La cusbooneysiiyay 01/21/16.
Mulhall, A., Droege, C., Ernst, N., Panos, R., iyo M. Zafar. Phosphodiesterase 4 inhibitor daaweyn loogu talagalay cudurka dabadheeraad ah ee joogtada ah: dib u eegida daawooyinka hadda iyo kuwa horumarinaya. Fikradaha Khibradda leh ee Mukhaadaraadka Baaritaanka . 2015. 24 (12): 1597-611.
Reid, D., iyo N. Pham. Roflumilast: daaweyn cusub oo loogu talagalay cudurada joogtada ah ee joogtada ah. Hawlaha Farshaxanka. 2012. 46 (4): 521-9.
Maktabadda Qaranka ee Dawada ee Maraykanka. MedlinePlus. Roflumilast La casriyeeyay 08/15/12. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a611034.html