Avodart iyo Proscar waa FDA-la ogolaaday inay daaweeyaan waxyeelada kaadi-mareenka ee ka imanaya ballaarinta prostate-ka . Magaca guud ee Avodart waa dutasteride; Magaca guud ee Proscar waa finasteride. Daawooyinkan, si kastaba ha ahaatee, waxay leeyihiin ficil balaadhan oo ficil ah oo ka badan inta ay si fudud u kobcinayaan shaqeynta kaadida. Waxay ka shaqeeyaan xannibidda nooc ka mid ah testosterone oo loo yaqaan dihydrotestestoneone (DHT) oo xoogga saaraya prostate-ka, kicinta si ay u koraan uguna soo saarto shahwada.
Marka DHT ay joojiso qanjidhada qanjirka 'prostate', waxay kordhisaa socodka kaadida.
Waxaa jira waxyaabo saameyn leh. Wax soo saarka semen inta badan waa la dhimay. Mararka qaarkood nimanku waxay soo sheegaan dhimista libido iyo awoodda. Sidoo kale, balaarinta naasuhu waxay dhici kartaa. Guud ahaan, saameynadaan soo socdaa waxay gashan doonaan ama yareeyaan ilaa inta daaweynta la joojiyo calaamada koowaad ee dhibaatada. Marka laga reebo faa'idooyinka kaadida, waxaa jira liis dheer oo ah faa'idooyin kale oo faa'iido leh.
Avodart or Proscar waa:
- PSA-da hoose waxaana yareyneysa halista lagu ogaado kansarka qanjirka 'prostate'
- Hagaajinta xaddiga lagu ogaanayo kansarka qanjirka 'prostate' ee ragga ee ku jira biopsiga
- Sababta keenta Gleason 6 kansarka (kansarka hooseeya) si uu u gooyo ama loo cadaadiyo
- Isku dheelitir daawooyinka kale ee loo isticmaalo daaweynta kansarka qanjirka 'prostate' sida Casodex ama Lupron
- Ka caawi dadka inay ilaaliyaan ilaalada firfircoon waxayna hoos u dhigaan khatarta ah in loo baahdo qalliin ama shucaac
- Iska yaree xayawaanka ragga
- Dib-u-dhigga orgaanmiga ragga oo leh hawo-la'aan quudhsasho ah
Saameynta Ka Hortagga Kansarka
Daraasad aan kala sooc lahayn oo la barbardhigay Proscar oo la yiraahdo placebo, 10,000 oo qof ayaa ku dhacay maqaayada qanjirka 'prostate' ka dib toddoba sano oo daaweyn ah. Ragga lagu yaqaan 'Proscar-treated' ayaa lagu ogaadey kansarka 25% marka la barbar dhigo ragga loo yaqaan 'placebo'.
Si kastaba ha ahaatee, xamaasad u ah isticmaalka joogtada ah ee Proscar si looga hortago kansarka ayaa cidhiidhi gashay sababtoo ah isku daraasad la mid ah ayaa sheegay in 1% ay kordheen dhacdooyinka lagu ogaado cudurka kansarka qanjirka 'prostate'.
Khabiirada wakhtigaas ayaa waxay muujinayaan in Profcar uu kordhiyay xaddiga lagu ogaanayo halkii uu keeni lahaa cudur heer-sare ah. Si kastaba ha ahaatee, Peter Scardino MD, oo ku takhasusay cilmi-baadhista caanaha ee Memorial Sloan Kettering ayaa daabacay fikradda ah in Proscar laga yaabo inuu keeno kansarka khatarta sare leh, kor u kicinta noocyada kala duwan ee qashinka ah iyo keenista FDA inay bixiso digniin. Dhammaan cabsiyadan ayaa ugu dambeyntii laga saaray bishii Agoosto 15, 2013 ee wargayska New England Journal of Medicine taas oo aan muujin dhimashada kansarka qanjirka 'prostate' ee ragga qabriga loo yaqaan 'Proscar' marka la barbar dhigo ragga lagu daaweeyo cirbado 18 sano ka dib.
Maaddaama Avodart iyo Proscar ay ka shaqeynayaan hab la mid ah, wax badan oo laga ogaado waxyeellada Proscar ayaa sidoo kale la oran karaa Avodart. Labada walxoodba waxay xannibayaan 5-alpha-reductase (5-AR), enzymes oo beddela testosterone galay DHT. Waxaa jira faa'iido muuqaal ah oo Avodart ah oo ka badan Proscar sababtoo ah Avodart waxay ka kooban tahay 5-AR enzyme si aad u fiican. Hase yeeshee, tijaabooyin tijaabo ah, si kastaba ha ahaatee, waxaa loo qabtay si loo barbardhigo labadan wakiil oo madax u ah.
Maadaama labadaba Proscar iyo Avodart ay PSA hoos u dhigtay qiyaastii 50%, su'aashu waxay soo baxaysaa, "Miyuu moodaa inuu awood u leeyahay PSA inay muujiso horumarka kansarka?" Si kooban, jawaabtu maya. Daawooyinkani ma joojinayaan PSA in ay sii korodho ragga qaba kansarka horay u sii kacaya. Si kastaba ha ahaatee, PSA waxay dib u dajineysaa heer hoose 50% ka dib marka la bilaabo Proscar ama Avodart. Celcelis ahaan, nin leh PSA 6.0 ka hor inta uusan billaabin Proscar wuxuu hoos u dhacayaa 3.0 dhawr bilood gudahood. Markaa kadib, haddii PSA ay si joogto ah kor ugu kacdo 3.0, horumarka kansarka ayaa u baahan inuu keeno sabab macquul ah.
Proscar iyo Avodart waxay u muuqdaan inay yeeshaan saameyno sahlan oo ay ku yar yihiin haddii ay jiraan wax isdhaafsan daawooyinka kale.
Marka waxyeellada soo gaarto, waxay u muuqdaan inay noqdaan kuwo la beddeli karo. Proscar iyo Avodart waa ku habboon yihiin, sababtoo ah waxa la qaadan karaa wakhti kasta oo maalinta ah, oo leh ama aan lahayn cunto. Finasteride, guud ahaan waxyeellada Proscar waa la heli karaa waana mid la awoodi karo. Qiimaha fiicnaanta leh iyo qaabka waxtarka daaweyntu waxay ka dhigeysaa tixgelin dheeraad ah oo loogu talagalay bukaanada qaba kansarka qanjirka 'prostate' ee raba inay xakameeyaan PSA iyaga oo wali sii wata nolol tayo fiican leh kharash yar.