Cunto qaadaha Kansarka Qanjidhka Qanjidhka - Markuu Shaqeynayo iyo Sidee Wanaagsan?
Sidee iyo goorma ayuu takhaatiirta (docetaxel) u shaqeeyaa daaweynta kansarka qanjirka 'prostate' ?
Sidee Loogu Daawan Doonaha Taksiga (Docetaxel)?
Taksaaqaha (docetaxel) wuxuu u shaqeeyaa daawooyinka kemotherabi ee badan adoo carqalaya qaybta unugyada (oo loo yaqaan mitosis). Maadaama unugyada kansarku ay yihiin qaar ka mid ah unugyada sida ugu dhakhsaha badan ee jidhka ku jira, unugyadaas ayaa doorbidaya saameynta ay ku yeelanayaan Taxotere iyo, markaa, waxay u dhintaan heerar sare marka daawada la qaato.
Marka laga reebo kansarka qanjidhka kaadimareenka, Taxotere waxaa loo isticmaali karaa dadka qaba noocyada kansarka sanbabada, kansarka naasaha, ama kansarka ugxan-sidaha.
Taariikhda - Cunto qaadaha Kansarka Kansarka Kansarka Horey Leh
Taxotere waxaa loo keenay qaybta daaweynta kansarka qanjirka 'prostate' ka dib markii daraasaddan lagu daabacay Wargeyska New England Journal of Medicine 2004 oo muujisay in Taktoeriyeyaashu ay la jaanqaadi doonaan saadaashii hore ee steroid taasoo keentay in la sii wanaajiyo badbaadada marka la barbardhigo daroogada ka dambeysa ee loogu talagalay kansarka ilmagaleenka , mitoxantrone. Qoraaga New Journal Journal ayaa sidoo kale muujiyay in nimankaas la daweeyay Taxotere ay lahaayeen guud ahaan tayada nolosha iyo hagaajinta xanuunka. Waqtigaas, Taxotere waxaa loo tixgeliyey daaweyn lagu doorto kansarka qanjirka 'prostate' ee ragga ee kaankarada kansarka qanjirka 'prostate' ku faafay ka hor intaan qanjirka laga qaadin oo uu ku adkeysto daaweynta hoormoonka .
Cunto-saaraha ayaa wali la tixgeliyaa doorasho wanaagsan (oo ay weheliyaan daawooyinka kale ee la baranayo) si loogu isticmaalo ragga qaba kansarka qanjirada 'prostate' kaasoo u adkaysiga daaweynta hoormoonka (daaweynta xakamaynta iyo hormoonka).
Iminka - Cunto qaadaha Kansarka Qanjidhka Qanjidhka Dhiigga ah ee Hormoon-hormarsan
Daraasado waaweyn sida tijaabada CHAARTED iyo kuwa kale ayaa beddelay qaabka kansarka qanjirka 'prostate' ee hore loogu talagalay ragga badan. Kansarradaas ayaa laga yaabaa in ay noqdaan kuwo aad u sarreeya xilliga baaritaanka ama ay noqdaan kuwo daaweyn ka dib markii daaweynta bilawga ah ee kansarka qanjirka 'prostate' .
Halka daaweynta takhtarka takhasuska hore loo isticmaalay ragga qaba kansarka qanjirka 'prostate' ee u adkaysatay daaweynta hoormoonka, waxay u muuqataa in la adeegsanayo daaweynta Taktooterere horay - isla mar ahaantaas daaweynta hormoonka daaweynta hormarineed - ayaa leh faa'iidooyinka labada bilaa horumar ah noolaanshaha iyo guud ahaan badbaadada. Dhab ahaan, Taktoortere waxay leedahay saameyno saameyn leh sida walxaha dawooyinka kemotherabi, laakiin taasi, iyo sidoo kale horumarinta daawooyinka kale, waa calaamad aad u xiiso leh oo lagu hormarinayo daaweynta kansarka qanjirka 'prostate'.
Cunto-qaadaha loogu talagalay Kansarka Kansarka Leh ee Degaanka ah
Maxkamadeynta STAMPEDE waxay soo qortey ragga qaba kansarka qanjirka 'prostate' ee gudaha. Ragga la siiyay daawada hormoonka ah ee hormoonka daweynta hoormoonka ayaa la ogaaday in ay haystaan daaweyn caafimaad la'aan iyo guud ahaanba ka badan kuwa loo daaweeyay daaweynta hoormoonka. Xayiraaddu waa in ragga ay yihiin kuwa ugu wanaagsan ee daaweyntan loogu talagalay ay yihiin kuwa qaba kansarka qanjirka 'prostate'.
Daaweynta Adjuvant ee Kansarka Qanjidhka Qanjidhka Leh ee Degdega ah
Ragga oo leh qanjirro heer sare ah oo heer sare ah oo khatarta sare leh, iyada oo la adeegsanayo Taxotere oo ku yaal meel adag ("xaalad" xaalad ") ayaa la ogaaday inay si weyn u yareeyso dhacdooyinka durugsanaanta fog (faafitaanka) kansarka qanjirka 'prostate'.
Raggaas waxaa lagu daaweeyay Taxotere oo lagu daray daaweynta hoormoonka iyo daaweynta shucaaca , halkii laga daaweyn lahaa daaweynta hoormoonka iyo daaweynta shucaaca. Dabcan, Taktootarer wuxuu leeyahay waxyeelo xun oo loo baahan yahay in la tixgeliyo.
Maxay Tahay Saameynada Laga Helo?
Sida dawooyinka kemotherabi oo dhan, waxaa jira waxyaabo badan oo kala duwan oo ka yimaada waxyeellada soo gaari karta marka la qaato takhtarka. Waxaa laga yaabaa inaad la socoto qaar ka mid ah kuwan oo ay ku badan yihiin noocyo badan oo kiimiko ah. Dhibaatooyinka soo socda waxay ku dhacaan in ka badan saddex meelood meel dadka isticmaala Takhtoonka:
- Cudurka neutropenia - Tirada unugyada cad ee dhiigga oo hoos u dhacda taas oo keeni karta caabuq.
- Anemia - Tirada unugyada dhiigga cas ee hooseeya taas oo keeni karta daal ka mid ah astaamaha kale.
- Dhimista timaha
- Ka qaadista dareeraha
- Shuban
- Lalabbo - Astaamadani sida caadiga ah waa mid si fiican loo xakameeyo daawooyinka ladagaallanka ee hadda jira
- Finan
- Nabaro afka ah
- Waxyaabaha isbeddelaya ayaa isbedelaya
- Dareen-celinta xasaasiyadda - Tani waa caan, daawooyinka si ay uga hortagaan calaamadaha xasaasiyadda waxaa badanaa la bixiyaa faleebada.
Ilaha:
Fizazi, K., Jenkins, C., iyo I. Tannock. Ma habboon tahay in docetaxel ay noqoto mid lagu daryeelo bukaanka qaba kansarka qanjirka 'prostate'? Pro iyo contra. Annals of Onology . 2015. 26 (8): 160-7.
Goodman, A. Docetaxel Combined With Therapy Therapy waxay kordhisaa Badbaadinta Kansarka Kansarka Horukacsan. Boostada ASCO . http://www.ascopost.com/issues/may-25,-2015/docetaxel-combined-with-hormone-therapy-extends-survival-in-advanced-prostate-cancer.aspx.
James, N., Sydes, M., Clarke, N. et al. Isku daridda maaddada 'doctaxel', zoledronic acid, ama labadaba daaweynta hoormoonka hormoonka muddada dheer ee kaansarka qanjirka 'prostate' (STAMPEDE): Natiijooyinka badbaadada ee ka soo baxa qalab isku-dhafan, isku-dhafan, kala-duwan, dhexdhexaad ah oo tijaabo ah. Lancet . 2015 Dec 21. (Epub ka hor daabac).
Martel CL, Gumerlock PH, Meyers FJ, et al. Istaraatijiyadaha hadda jira ee maaraynta hormoonka kansarka qanjirka 'prostate'. Cancer Treat Rev. 2003; 29: 171-187.
Machadka Kansarka Qaranka. Daraasad lagu maalgeliyo NIH waxay muujinaysaa in korodhka noolaanshaha ee ragga qaba kansarka qanjirka 'prostate' ee qaata kiimiko ku daawaynta marka la bilaabayo daweynta hormoonka. http://www.cancer.gov/news-events/press-releases/2013/E3805.
Tannock IF, de Wit R, Berry WR, et al. Docetaxel iyo prednisone ama mitoxantrone iyo prednisone kansarka qanjirka 'prostate'. N. Engl. J. Med. 351 (15): 1502-12.