Jinsiyada aad ka dhaxashay waalidkaaga ayaa go'aamiya muuqaalka jirkaaga, sida midabka indhaha iyo lafaha, iyo sidoo kale astaamaha kale, sida nooca dhiigga iyo u dhawaanshaha. Taasina ma ahan. Jeermisyada unugyada ayaa sidoo kale kaa caawin kara qeexida qaar ka mid ah awoodaada jirka ee jirka - sida ka hortagga kansarka qanjirka 'prostate' ka soo noqosho.
Sidee Kansarka Qanjidhka Lagu Qaadaa
Androgens (hormoonada labka jinsi) waxay sameeyaan kansarka qanjirka 'prostate'.
Sidaa daraadeed, daaweynta xanuunka quudinta iyo hormoonnada (ADT) waa hal dariiq oo lagu daaweyn karo kansarka qanjirka 'prostate' , gaar ahaan marka uu kordho ama uu faafo. ADT waxay ku lug yeelan kartaa qaadashada daawooyinka joojiya inrogen laga soo saaro (xiniinyaha) ama xannibo saameynta oogada oo dhan jirkaaga. ADT ayaa sidoo kale ku lug leh qalliinka si looga saaro labadaba. Waxaa badanaa la isticmaalaa marka lagu daro daaweynta kansarka qanjirka 'prostate', sida daaweynta shucaaca ama ka saarida qanjirka 'prostate'.
ADT, dhab ahaantii, waxay saaraysaa shidaalka waxayna joojisaa unugyada kansarka qanjirada 'prostate' ka soo koraya - ama ugu yaraan hoos u dhigo.
Laakiin, xaaladaha badankood, ADT waxay u shaqeysaa muddo dheer. Unugyada kansarka qanjidhka 'prostate' ayaa badanaaba noqda "xakamaynta adkeysiga". Waxay bilaabaan inay sameystaan caruurtooda, iyo markaa iskahorimidooda.
Ragga qaata ADT ee kansarka qanjirka 'prostate' waxay leeyihiin baaritaano joogto ah oo qanjirka 'prostate-antigen' (PSA) . Kordhinta heerka PSA waxay muujin kartaa in kansarka qanjirka 'prostate' uu noqday mid iska caabin ah oo uu bilaabay inuu koro mar kale.
Cudurka Qaadista Awoodahaaga Kansarka Kansarka qanjirka 'Prostate'
Ragga qaarkood waxay isticmaali karaan ADT si loo ilaaliyo kansarka qanjirka 'prostate' ka ee ka dheer kuwa kale.
Daraasad 2016-ka Cleveland Clinic iyo Mayo Clinic waxay ogaatay in ragga qaba noocyo kala duwan oo ah hiddaha khaaska ah ay u badan tahay inay helaan kansarka naas-nuujinta ka hor intaan la helin. Raggaas, ADT ma shaqeynayo muddo dheer.
Kansarka ayaa si dhakhso ah u soo kabanaya.
Qiyaas ahaan 443 oo bukaan ah oo qaba kansarka qanjirada daraasaddan, dhammaantood waxay lahaayeen cudur halis ah waxaana lagu daaweeyay ADT. Ragga qaarkood waxay leeyihiin gen " HSD3B1 " caadi ah - laba koobi, mid ka mid ah waalid kasta. Qaar kale waxay lahaayeen nooc, HSD3B1 (1245C), laakiin keliya hal waalid. Hase yeeshee kuwa kale waxay leeyihiin hiddaha kala duwan ee labada waalid.
Nuqullada badan ee hidda kala duwan, ayaa ADT ka shaqeysay.
Dadka qaba "caadiga ah" ee kooxda Cleveland Clinic ee bukaannada ayaa joojiyay kansarka qanjirka 'prostate' si ay ugu soo noqoto dhexdhexaad 6.6 sano. Qaar kalena wax uma qabtaan. Kuwa leh hidda kala duwan ee hal waalid ayaa dib u soo noqoshada dhexdhexaad ah 4.1 sano. Kuwa leh hidda-wadaha kala duwan ee labada waalid ayaa dib-ugu-soo noqoshada dhexdhexaad ah 2.5 sano oo keliya.
Ma haysataa hiddaha kala duwan?
Sida laga soo xigtay mashruuca Genomes 1000, qiyaas ahaan kala badh ragga raga iyo dumarku waxay leeyihiin hiddaha HSD3B1 (1245C) - midkood ama labadaba.
Hada iminka, ma jirto tijaabo sahlan oo lagu aqoonsan karo (inkastoo lagu aqoonsan karo guddi buuxa ah). Cilmi-baaris dheeraad ah ayaa loo baahan yahay ka hor intaan HSD3B1 (1245C) -kabaabin dhiig-baadhis loo sameeyey si ballaadhan loo heli karo.
Waa maxay sababta aan hadda? Maadaama aysan jirin caddayn ku filan in bedelidda daaweynta ragga qaba hiddaha kala duwan ay kor u qaadi doonaan natiijada.
Waxaan hadda samaynaa cilmi baaris dheeri ah si aan u aragno haddii daaweynta hormoonnada kale ee caafimaadku ay ka fiicnaan doonto ADT raggaas. Haddii ay sidaas sameeyaan, waxan haynaa caddayn in baaritaanka dhiigga ee fudud la soo bandhigo HSD3B1 (1245C).
Daaweynta Shakhsi ahaaneed waxay noqon kartaa mid guul leh
Maanta waxaanu u daaweynaa dhammaan bukaanada qaba kansarka qanjirka 'prostate' sida waafaqsan halbeeg daryeel. Laakiin cilmi-baaris ayaa noo horseedi karta in aan shakhsiyan ku daweyno iyadoo lagu saleynayo astaamaha bukaanka.
In mustaqbalka aan fogeyn, waxaan rajeyneynaa in aan isticmaalno baaritaanka hidda-socodka si loo go'aamiyo bukaanka u baahan daaweynahan, halkii laga daaweyn lahaa qof walba isku mid.
Tusaale ahaan, bukaanka aan haysan HSD3B1 (1245C) ayaa laga yaabaa inay si fiican ula qabsadaan ADT. Kuwa ay la socdaan waxaa laga yaabaa in ay u baahdaan daaweyn khatar ah.
Dr. Shariff waa dhakhtar oncologist oo ka shaqeeya Machadka Kansarka Taussig ee Cleveland Clinic oo haya Kendrick Family Chair for Research for Cancer Research ee Cleveland Clinic.
> Ilo:
> Hearn JW, Abuali G, Reichard CA, iyo al. HSD3B1 iyo iska-caabbinta daaweynta xannibaadaha iyo quudinta ee ku jira kansarka qanjirka 'prostate': Daraasad cilmi baaris ah, daraasad badan. Lancet Oncol. 2016; 17 (10): 1435-1444.