Nodular sclerosing Hodgkin lymphoma, kansar qanjidhada unugyada, waa nooca cudurka Hodgkin. Waa nooca ugu caansan ee Hodgkin lymphoma ee dalalka horumaray, oo u dhiganta 60 illaa 80 boqolkiiba dhammaan dadka ay saameeyeen cudurkan.
Noocyada muruqyada ee 'Hodgkin Lymphoma' ayaa saameynaya inta badan dhalinyarada iyo dadka da'da yar. Sidoo kale gabdhaha waa wax aad u yar oo ka weyn wiilasha.
Magaca 'nodular sclerosing' waxaa laga soo qaatay muuqaalka muuqaalka nudaha lymph node ee ku yaala mikroskoob ee noocaan ah Hymgga Lymphoma.
Astaamaha ugu muhiimsan ee calaamadaha nodular ee Hodgkin Lymphoma waa qanjidhada qanjirada ee qoorta, kilkilooyinka ama laabta . Ciladda lymphoma waxaa lagu sameeyaa qanjidhada qanjirada naqaska.
Dadka badankood waxaa lagu ogaadaa marxaladaha hore waxaana lagu daaweyn karaa daaweyn ay ka mid yihiin daaweynta kiimiko iyo daaweynta shucaaca.
Mid ka mid ah Hodgkin Lymphomas kala duwan
Magacyada dhammaan noocyada lymphoma iyo subtypes ayaa jahwareeraya xitaa dhakhaatiirta aan si joogto ah ula macaamilin. Cudurka Hodgkin iyo Hodgkin lymphoma micnaheedu waa wax la mid ah, hase yeeshee, waxaa jira noocyo badan oo kala duwan oo lymphoma ah, kuwaas oo Hodgkin ay tahay hal keliya. Waxa kale oo jira noocyo badan oo kala duwan oo lymphoma ah. Sidaa daraadeed, halkan waa juujinta qanjidhada nodular ee Hodgkin lymphoma marka la eego meesha ay ku haboon tahay sawirka weyn ee dhammaan lymphomas:
Labada qaybood ee aasaasiga ah ee lymphoma waa Hodgkin iyo Non-Hodgkin lymphoma.
Dhiigga Hodgkin wuxuu markaa sii deyn karaa laba kooxood:
- Lymphoma-Classic Hodgkin - oo leh dhowr subtypes
- Lymphocyte-Nodular lymphocyte-Predominant Lymphoma
"Nodular lymphocyte predominant" iyo "nodular sclerosing" ma aha wax la mid ah - waxay tilmaamayaan laba nooc oo kala duwan oo ah noocyada Hodgkin Lymphoma.
Nodular Sclerosing Hodgkin Lymphoma - Lymphoma oo hadda la sharaxay - waa nooc hoosta ah ee Lymphoma Classic Hodgkin. Lymphoma Classic Hodgkin wuxuu leeyahay afarta subtypes ee soo socda:
- Maqasaasaha Nodular
- Qalabka isku dhafan
- Lymphocyte-hodan
- Lymphocyte-dhicin.
Cusbooneysiinta: Calaamadaha Noodlaha (Classic Scooter) Classic Hodgkin Lymphoma
Nodular Sclerosis Hodgkin Lymphoma (NSHL) ayaa ah kuwa ugu caansan nudaha unugyada ku salaysan unugyada-yar-yar ee dhalinyarada iyo dhalinyarada ku nool waddamada warshadaha. NSHL waxay kaloo leedahay qayb adag oo dhaxal gal ah, iyada oo 100 dhibcood oo halis ah ay u tahay laba mataano oo isku mid ah.
Dhowaan, waxaa jiray baadhitaan ballaaran oo lagu sameeyey ururka shucaaca ultraviolet ee qorraxda iyo noocyada kala duwan ee Hodgkin lymphoma. Daraasada ay sameeyeen Emily Bowen iyo asxaabtiisaba, Hodgkin lymphoma xaaladiisu waxay ka hooseeyaa dadka ay ku jiraan sunta ugu sarreeya ee qoraxda. In kasta oo natiijadani ay ahayd mid isbeddel ah, kaliya, isbeddelladan ayaa u muuqday in ay qabteen dad run ah oo hoos udhaca sheybaarada noodhada.
Daraasado kale oo dhowaan la sameeyay waxay sahamiyeen daaweyn gaar ah, kontoroolka difaaca jirka, iyo sida ay ula falgalaan geedi socodyo kala duwan oo loo yaqaanno in ay ku socdaan noocyo gaar ah ee HL.
Daraasad uu soo saaray Peter Hollander iyo jalayaashiisa ayaa sheegay in xakamaynta koontaroolka difaaca jirka ee lagu beegsanayo baraha dhimirka ee barnaamijka dhimashada (PD) -1 waa hab cusub oo daaweyn ah oo loo maro laf-dhabarka cusub ee Hodgkin.
Kooxdani waxay ogaatay in dabeecadaha qaarkood ee unugyada laga helo dhammaanba hareeraha bukaanka, oo aan ahayn unugyada tumingka naftooda, waxay ku xiran yihiin saadaasha. Daraasadan ayaa lagu ogaaday in natiijooyinka ka soo baxa Qaabdhismeedka caadiga ah ay ka sii daran yihiin marka unugyada dhiiga cad, ama unugyada microenvironment, ay ku jiraan tirada badan ee samaynta PD-1 iyo PD-L1. Waxay soo jeediyeen in kooxahan hoose ee bukaanku ay ka faa'iideysan karaan nidaamyo badan oo khatar ah oo kiimiko ah iyo, laga yaabo, inay ka hortagaan daawada PD-1 sida daaweynta hore.
> Ilo:
> Cozen W, Li D, Best T, et al. Falanqaynta maadada-qotomiska ee miyir-qabadka nodular ee Hodgkin Lymphoma ayaa qeexaya halista halista ah ee 6p21.32. Dhiiga. 2012; 119 (2): 469-475.
> Hollander P, Kamper P, Ekstrom K, et al. Saameynta sare ee PD-1 + iyo PD-L1 + leukocytes ee hodgkin lymphoma microenvironment waxay la xiriirtaa natiijada liidata. Dhiiga Dhiiga. 2017; 1 (18): 1427-1439.
> Bowen EM, Pfeiffer RM, Linet MS, et al. Xidhiidhka u dhexeeya shucaaca ultraviolet-ka ee jirka iyo Hodgkin lymphoma subtypes ee Maraykanka. British Journal of Cancer. 2016; 7 (7): 826-831.