Xaalad la yiraahdo loo yaqaan 'chipotherapy-induced neuropathy' (CIPN), daawooyinka qaarkood ee loo isticmaalo daaweynta kansarka waxay waxyeelo u geystaan ​​neerfahaaga.
Qalbiyadaaga agagaarku waxay leeyihiin calaamadaha maskaxda iyo xangulada laf dhabarta muruqyadaada si dhaqso ah u dhaqdhaqaaqa. Waxay sidoo kale ku hayaan macluumaadka dareenka ah ee maskaxda iyo xangulada laf-dhabarka.
Astaamaha
Daaweynta neeropathy-ku- dhalashada ee kemotherabi-kiimistosku wuxuu sababi karaa calaamado kala duwan oo ku xiran nabraha dareen-celiska ah ee la saameeyey.
Tusaalooyinka calaamadaha caamka ah waxaa ka mid ah:
- Kabuubis
- Qulqulaya, sida "biinanka iyo irbadaha" dareenka
- Gubashada gacmahaaga iyo cagahaaga
- Ku dhufo ama dilida xanuunka daran ee laga yaabo in uu kala gooyo ama joogteynayo
- Dhibaatooyinka dheelitirka
- Geynta sheyga
- Socodka
Maadaama ay dareemayaasha dareenka xakameynaya kaadiheysta iyo mindhicirkaaga, daaweynta neeropathy-ku-dhaliye ee kemotherabi-ku-daweyntu waxay u horseedi kartaa calool-istaagga ama dhibaatooyinka kaadida.
Sababaha
Sida laga soo xigtay Society Cancer Society, halkan waa daawooyinka kiimikada ee ugu badan ee la xidhiidha keenista CIPN:
- Daawooyinka Platinum sida Cisplatin, Carboplatin, iyo Oxaliplatin
- Taxane sida Taxol (paclitaxel), Taxotere (docetaxel), iyo Jevtana (cabazitaxel)
- Epothilones sida Ixempra (ixabepilone)
- Alamoids beer sida vinblastine, vincristine, vinorelbine, iyo etoposide (VP-16)
- Thalomid (thalidomide), Revlimid (lenalidomide), iyo Pomalyst (pomalidomide)
- Velcade (bortezomib) iyo Kyprolis (carfilzomib)
- Halaven (eribulin)
Dabcan, sababtoo ah waxaa lagu siiyaa hal ama in ka badan daawooyinka kiimikada ee kor ku xusan, macnaheedu maahan inaad hubinayso inaad CIPN ku horumarin doonto.
Waxaa jira doorsoomayaal badan oo khatarta ah, sida qiyaasta daawada, daroogada la isku siiyay, iyo da'daada.
Ka hortagga
Haddii neuropathy uu noqdo mid xun, waxa laga yaabaa inaanay saameyn ku yeelan doonin tayada noloshaada, laakiin waxay faragalin kartaa daaweyntaada, gaar ahaan haddii aad u baahan tahay inaad isticmaasho qadar yar oo kemotherabi ah sababtoo ah calaamadaha dhibbanaha.
Nasiib darro, ma jiraan daweyno la aqoonsan yahay oo FDA loogu talagalay ka hortagga neuropathy ee la xiriira kiimiko. Si kastaba ha noqotee, waxaa jiray dhowr daaweyn oo la isku dayay; inkastoo caddaymaha sayniska ay taageerayaan ay yihiin kuwo isku mid ah, ama midkoodna midkoodna.
L-Glutamine
Taasi waxay tidhi, mid ka mid ah lacagaha la soo bandhigay (laga yaabee in ka badan si joogto ah dadka kale) si ay u yeeshaan saameyn difaac ah ee dareemayaasha waa L-glutamine. Xoojintaas waxaa la rumeysan yahay in ay ka shaqeyneyso adigoo sameysanaya daboolida dareenka gacmaha, cagaha, iyo habka dheef-shiidka. Tani waxay "saameyneysaa saamaynta" waxay yareysaa ama jabisaa waxyeelada keeni karta kiimiko.
Xaqiiqdii, daraaseyn dib-u-eegis ah ee Falanqaynta Khatarta ah ee Oncology / Hematology waxay soo xigatay L-glutamine sida ballanqaadka ah ee looga hortagayo dhacdooyinka iyo darnaanta khatarta neeropathy-kemotherapy.
Dabcan, in kastoo glutamine uu u muuqdo mid aad u ammaan badan oo aan u muuqan in uu faragalinayo daaweynta kansarka (ugu yaraan daraasado ilaa taariikhda) waa muhiim inaad la hadasho dhakhtarkaaga ka hor intaadan qaadan wax dheeri ah ama fitamiin.
Tani waa sababta oo ah waxtarka iyo fitamiinada, inta badan loo yaqaan "dabiiciga ah", had iyo jeer ma aha mid amaan ah. Xaqiiqdii, mid ka mid ah daaweynta dabiiciga ah, acetyl - l - carnitine, oo loo maleynayay inay suurtogal tahay in laga caawiyo horay, ayaa dhab ahaantii ka sii dari kara neuropathy oo la xidhiidha kemotherabi.
Intaa waxaa dheer, walxahan "dabiiciga ah" waxay la macaamilaan daaweynta kansarka, xitaa yaraynta waxtarka.
Dhammaan, haddii dhakhtarkaagu ku raaco in glutamine ay labadiinuba badbaado iyo waxtar kuu lahaan karaan, weydii qiyaasta ay ku talinayso. Qiyaasta caadiga ah waa 15 milligram maalintii, laba jeer maalintii, inkastoo wakhtigaas la bilaabi doono iyo mudada loo isticmaalo isticmaalka dheeraadka ah waxay ku kala duwanaan doontaa iyadoo ku xiran habka daaweynta kemotherabi ee gaarka ah.
Daawooyinka kale ee Ka hortaga
Daawooyinka kale ee laga yaabo inay ka hortagaan CIPN, waxaa ka mid ah fitamiin E iyo omega-3 dufan ah, inkastoo mar kale, sayniska taageerada waxtarkooda waa kooban yahay. Ka sokow daawooyinka iyo fitamiinada, daawooyinka rijeetooyinka ah ee laga yaabo inay ka hortagaan CIPN waxaa ka mid ah
- Qaar ka mid ah antidepressants sida Effexor (venlafaxine)
- Qaar ka mid ah dawooyinka ladagaallanka suuxinta sida Tegretol (carbamazepine)
Ereyga
Cudurka neeropathy ee ka yimaadda kemotherabi wuxuu noqon karaa dhibaato naafo ah, ma aha oo kaliya raaxo daro keenta laakiin sidoo kale waxay sababi kartaa saameynta daaweyntaada guud ee kansarka.
Si kastaba ha ahaatee, waa muhiim inaad u sheegto dhakhtarkaaga haddii aad ku aragto calaamadaha cudurka neuropathy-iyo sida ugu dhakhsaha badan ee ugu fiican, sida dhibaatada wax looga qabanayo isla markiiba waxay ka hortagi kartaa neuropathy inuu noqdo mid daba joog ah.
> Ilo:
> Bulshada Mareykanka ee Kansarka. Cudurka Neuropathy ee Peripheral Neuropathy oo ay keento Chemotherapy.
> Brami, C., Bao, T., iyo G. Deng. Waxyaabaha dabiiciga ah iyo daaweyn dhameystiran oo loogu talagalay daaweynta neeropathy-ku-dhaliye-kiimiko-kiimiko: daweyn nidaamsan. Warbixinnada Halista ah ee Onkology iyo Hematology . 2016. 98: 325-34.
> Machadka Dana Farber Cancer Institute. Ciladaynta Calaamadaha Cudurka Nafaqeeyayaalka Cudurka ah. La helay 03/05/16. http://www.dana-farber.org/Health-Library/Alleviating-Peripheral-Neuropathy-Symptoms.aspx
> Wang, W., Lin, J., Lin, T. et al. Galka glutamine waa mid waxtar u leh ka hortagga cudurka neeropathy ee oxaliplatin ee bukaanka kansarka mindhicirka. Oncologist . 2007. 12 (3): 312-9.